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Hyperhomocysteinemia, atherosclerosis and thrombosis.
Thromb Haemost 1999; 81(2):165-76TH

Abstract

High plasma levels of homocysteine are the results of the interplay between congenital and environmental factors. In the last two decades, a growing amount of interest has focused on mild-to-moderate hyperhomocysteinemia as a risk factor of thromboembolic diseases. Case-control and cross-sectional studies clearly indicated that mild-to-moderate hyperhomocysteinemia is associated with heightened risk of both arterial and venous thrombosis. On the other hand, prospective studies did not unequivocally show that hyperhomocysteinemia is associated with a high thrombotic risk. Therefore, additional studies are needed to define whether hyperhomocysteinemia is a risk factor for thrombosis, especially of the venous circulation. Among these, prospective cohort studies will clarify better the temporal relationship between high homocysteine levels and the thrombotic event. Most importantly, however, randomized, placebo-controlled, double-blind trials of the effects of homocysteine-lowering vitamins on the thrombotic risk are urgently needed. Not only will they help in defining whether the relationship between hyperhomocysteinemia and thrombosis is causal, they will also have a potential dramatic impact in the prevention of thromboembolic events.

Authors+Show Affiliations

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Italy. marco.cattaneo@unimi.it

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10063987

Citation

Cattaneo, M. "Hyperhomocysteinemia, Atherosclerosis and Thrombosis." Thrombosis and Haemostasis, vol. 81, no. 2, 1999, pp. 165-76.
Cattaneo M. Hyperhomocysteinemia, atherosclerosis and thrombosis. Thromb Haemost. 1999;81(2):165-76.
Cattaneo, M. (1999). Hyperhomocysteinemia, atherosclerosis and thrombosis. Thrombosis and Haemostasis, 81(2), pp. 165-76.
Cattaneo M. Hyperhomocysteinemia, Atherosclerosis and Thrombosis. Thromb Haemost. 1999;81(2):165-76. PubMed PMID: 10063987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocysteinemia, atherosclerosis and thrombosis. A1 - Cattaneo,M, PY - 1999/3/4/pubmed PY - 1999/3/4/medline PY - 1999/3/4/entrez SP - 165 EP - 76 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 81 IS - 2 N2 - High plasma levels of homocysteine are the results of the interplay between congenital and environmental factors. In the last two decades, a growing amount of interest has focused on mild-to-moderate hyperhomocysteinemia as a risk factor of thromboembolic diseases. Case-control and cross-sectional studies clearly indicated that mild-to-moderate hyperhomocysteinemia is associated with heightened risk of both arterial and venous thrombosis. On the other hand, prospective studies did not unequivocally show that hyperhomocysteinemia is associated with a high thrombotic risk. Therefore, additional studies are needed to define whether hyperhomocysteinemia is a risk factor for thrombosis, especially of the venous circulation. Among these, prospective cohort studies will clarify better the temporal relationship between high homocysteine levels and the thrombotic event. Most importantly, however, randomized, placebo-controlled, double-blind trials of the effects of homocysteine-lowering vitamins on the thrombotic risk are urgently needed. Not only will they help in defining whether the relationship between hyperhomocysteinemia and thrombosis is causal, they will also have a potential dramatic impact in the prevention of thromboembolic events. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/10063987/Hyperhomocysteinemia_atherosclerosis_and_thrombosis_ L2 - http://www.diseaseinfosearch.org/result/7087 DB - PRIME DP - Unbound Medicine ER -