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Test-retest variability of frequency-doubling perimetry and conventional perimetry in glaucoma patients and normal subjects.
Invest Ophthalmol Vis Sci. 1999 Mar; 40(3):648-56.IO

Abstract

PURPOSE

To compare the test-retest variability characteristics of frequency-doubling perimetry, a new perimetric test, with those of conventional perimetry in glaucoma patients and normal control subjects.

METHODS

The study sample contained 64 patients and 47 normal subjects aged 66.16+/-11.86 and 64.26+/-7.99 years (mean +/- SD), respectively. All subjects underwent frequency-doubling perimetry (using the threshold mode) and conventional perimetry (using program 30-2 of the Humphrey Field Analyzer; Humphrey Instruments, San Leandro, CA) in one randomly selected eye. Each test was repeated at 1-week intervals for five tests with each technique over 4 weeks. Empirical 5th and 95th percentiles of the distribution of threshold deviations at retest were determined for all combinations of single tests and mean of two tests, stratified by threshold deviation. The influence of visual field eccentricity and overall visual field loss on variability also were examined.

RESULTS

Mean test time with frequency-doubling perimetry in patients and normal control subjects was 5.90 and 5.25 minutes, respectively, and with conventional perimetry was 17.20 and 14.01 minutes, respectively. In patients, there was a significant correlation between the results of the two techniques, in the full field and in quadrants, whereas in normal subjects there was no such correlation. In patients, the retest variability of conventional perimetry in locations with 20-dB loss was 120% (single tests) and 127% (mean tests) higher compared with that in locations with 0-dB loss. Comparative figures for frequency-doubling perimetry were 40% and 47%, respectively. Variability also increased more with threshold deviation in normal subjects tested with conventional perimetry. In both patients and normal subjects, variability increased with visual field eccentricity in conventional perimetry, but not in frequency-doubling perimetry. Both techniques showed an increase in variability with overall visual field damage.

CONCLUSIONS

Frequency-doubling perimetry has different test-retest variability characteristics than conventional perimetry and may have potential for monitoring glaucomatous field damage.

Authors+Show Affiliations

Department of Ophthalmology, Dalhousie University, Halifax, Nova Scotia, Canada.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10067968

Citation

Chauhan, B C., and C A. Johnson. "Test-retest Variability of Frequency-doubling Perimetry and Conventional Perimetry in Glaucoma Patients and Normal Subjects." Investigative Ophthalmology & Visual Science, vol. 40, no. 3, 1999, pp. 648-56.
Chauhan BC, Johnson CA. Test-retest variability of frequency-doubling perimetry and conventional perimetry in glaucoma patients and normal subjects. Invest Ophthalmol Vis Sci. 1999;40(3):648-56.
Chauhan, B. C., & Johnson, C. A. (1999). Test-retest variability of frequency-doubling perimetry and conventional perimetry in glaucoma patients and normal subjects. Investigative Ophthalmology & Visual Science, 40(3), 648-56.
Chauhan BC, Johnson CA. Test-retest Variability of Frequency-doubling Perimetry and Conventional Perimetry in Glaucoma Patients and Normal Subjects. Invest Ophthalmol Vis Sci. 1999;40(3):648-56. PubMed PMID: 10067968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Test-retest variability of frequency-doubling perimetry and conventional perimetry in glaucoma patients and normal subjects. AU - Chauhan,B C, AU - Johnson,C A, PY - 1999/3/6/pubmed PY - 1999/3/6/medline PY - 1999/3/6/entrez SP - 648 EP - 56 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 40 IS - 3 N2 - PURPOSE: To compare the test-retest variability characteristics of frequency-doubling perimetry, a new perimetric test, with those of conventional perimetry in glaucoma patients and normal control subjects. METHODS: The study sample contained 64 patients and 47 normal subjects aged 66.16+/-11.86 and 64.26+/-7.99 years (mean +/- SD), respectively. All subjects underwent frequency-doubling perimetry (using the threshold mode) and conventional perimetry (using program 30-2 of the Humphrey Field Analyzer; Humphrey Instruments, San Leandro, CA) in one randomly selected eye. Each test was repeated at 1-week intervals for five tests with each technique over 4 weeks. Empirical 5th and 95th percentiles of the distribution of threshold deviations at retest were determined for all combinations of single tests and mean of two tests, stratified by threshold deviation. The influence of visual field eccentricity and overall visual field loss on variability also were examined. RESULTS: Mean test time with frequency-doubling perimetry in patients and normal control subjects was 5.90 and 5.25 minutes, respectively, and with conventional perimetry was 17.20 and 14.01 minutes, respectively. In patients, there was a significant correlation between the results of the two techniques, in the full field and in quadrants, whereas in normal subjects there was no such correlation. In patients, the retest variability of conventional perimetry in locations with 20-dB loss was 120% (single tests) and 127% (mean tests) higher compared with that in locations with 0-dB loss. Comparative figures for frequency-doubling perimetry were 40% and 47%, respectively. Variability also increased more with threshold deviation in normal subjects tested with conventional perimetry. In both patients and normal subjects, variability increased with visual field eccentricity in conventional perimetry, but not in frequency-doubling perimetry. Both techniques showed an increase in variability with overall visual field damage. CONCLUSIONS: Frequency-doubling perimetry has different test-retest variability characteristics than conventional perimetry and may have potential for monitoring glaucomatous field damage. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/10067968/Test_retest_variability_of_frequency_doubling_perimetry_and_conventional_perimetry_in_glaucoma_patients_and_normal_subjects_ L2 - https://iovs.arvojournals.org/article.aspx?volume=40&issue=3&page=648 DB - PRIME DP - Unbound Medicine ER -