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Osteoporosis in adult patients with celiac disease.
Bone 1999; 24(3):249-55BONE

Abstract

We investigated the bone mineral density (BMD) and prevalence of osteopenia and osteoporosis in adult celiac patients with varying disease states. In this cross-sectional study the data on the severity of celiac disease and BMD were collected from 77 celiac patients (28 newly diagnosed and 49 previously diagnosed celiac patients), and BMD results were compared with those of 157 control subjects matched for age, gender, and menopausal status. The celiac patients had significantly lower BMD than the control subjects at the lumbar spine (-6%) and femoral neck (-5%). The mean BMD did not differ significantly among celiac patients classified by severity of disease. Based on Z scores, 35% of the celiac patients and 17% of the control subjects had low BMDs for age at the lumbar spine (p = 0.005), whereas 31% of celiac patients and 16% of control subjects had Z scores of < or =-1 at the femoral neck (p = 0.01). Altogether, 26% of all celiac patients, but only 5% of control subjects, were classified as having osteoporosis (T score < or =-2.5 SD) at the lumbar spine (p = 0.03), whereas osteoporosis was rare at the femoral neck in both groups (3% vs. 1%, p = 1.00). Prevalence of osteopenia and osteoporosis was highest in newly diagnosed celiac patients and in patients with disease not in remission. A low 25-(OH)D vitamin concentration was a typical biochemical abnormality in our patients (64% of men and 71% of women). The main associated variables of low BMD were age (men), low serum vitamin D level, low body weight, and postmenopausal status (women). The present study suggests that celiac disease constitutes a risk factor for osteoporosis. This finding applies particularly to untreated and poorly treated patients.

Authors+Show Affiliations

Department of Clinical Nutrition, Kuopio University Hospital and University of Kuopio, Finland. tarja.kemppainen@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10071918

Citation

Kemppainen, T, et al. "Osteoporosis in Adult Patients With Celiac Disease." Bone, vol. 24, no. 3, 1999, pp. 249-55.
Kemppainen T, Kröger H, Janatuinen E, et al. Osteoporosis in adult patients with celiac disease. Bone. 1999;24(3):249-55.
Kemppainen, T., Kröger, H., Janatuinen, E., Arnala, I., Kosma, V. M., Pikkarainen, P., ... Uusitupa, M. (1999). Osteoporosis in adult patients with celiac disease. Bone, 24(3), pp. 249-55.
Kemppainen T, et al. Osteoporosis in Adult Patients With Celiac Disease. Bone. 1999;24(3):249-55. PubMed PMID: 10071918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteoporosis in adult patients with celiac disease. AU - Kemppainen,T, AU - Kröger,H, AU - Janatuinen,E, AU - Arnala,I, AU - Kosma,V M, AU - Pikkarainen,P, AU - Julkunen,R, AU - Jurvelin,J, AU - Alhava,E, AU - Uusitupa,M, PY - 1999/3/11/pubmed PY - 1999/3/11/medline PY - 1999/3/11/entrez SP - 249 EP - 55 JF - Bone JO - Bone VL - 24 IS - 3 N2 - We investigated the bone mineral density (BMD) and prevalence of osteopenia and osteoporosis in adult celiac patients with varying disease states. In this cross-sectional study the data on the severity of celiac disease and BMD were collected from 77 celiac patients (28 newly diagnosed and 49 previously diagnosed celiac patients), and BMD results were compared with those of 157 control subjects matched for age, gender, and menopausal status. The celiac patients had significantly lower BMD than the control subjects at the lumbar spine (-6%) and femoral neck (-5%). The mean BMD did not differ significantly among celiac patients classified by severity of disease. Based on Z scores, 35% of the celiac patients and 17% of the control subjects had low BMDs for age at the lumbar spine (p = 0.005), whereas 31% of celiac patients and 16% of control subjects had Z scores of < or =-1 at the femoral neck (p = 0.01). Altogether, 26% of all celiac patients, but only 5% of control subjects, were classified as having osteoporosis (T score < or =-2.5 SD) at the lumbar spine (p = 0.03), whereas osteoporosis was rare at the femoral neck in both groups (3% vs. 1%, p = 1.00). Prevalence of osteopenia and osteoporosis was highest in newly diagnosed celiac patients and in patients with disease not in remission. A low 25-(OH)D vitamin concentration was a typical biochemical abnormality in our patients (64% of men and 71% of women). The main associated variables of low BMD were age (men), low serum vitamin D level, low body weight, and postmenopausal status (women). The present study suggests that celiac disease constitutes a risk factor for osteoporosis. This finding applies particularly to untreated and poorly treated patients. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/10071918/Osteoporosis_in_adult_patients_with_celiac_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(98)00178-1 DB - PRIME DP - Unbound Medicine ER -