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Effects of tetrahydroprotoberberines on dopamine D2 receptors in ventral tegmental area of rat.
Zhongguo Yao Li Xue Bao. 1997 Mar; 18(2):143-6.ZY

Abstract

AIM

To compare the actions of tetrahydroprotoberberines (THPB) on dopamine (DA) D2 receptors in the ventral tegmental area (VTA) of rat.

METHODS

Extracellular single unit recording technique was used in i.v. gallamine-paralyzed rats.

RESULTS

Eleven THPB analogs tested completely attenuated the apomorphine (Apo, 20 micrograms.kg-1)-induced inhibition on VTA DA cell firing activity. The OH group on C2 at THPB was linked with the reversal of Apo-induced inhibition. Their reversal potencies (ED50, microgram.kg-1) for D2 receptors were: THPB-143 (5.6) > SPD (8.5) > Iso (17.0) > THP (33) > THB (48) > THPB-18 (66) > THPB-1 (179) > THPB-19 (408) > THPB-126 (510) > THPB-104 (1019) > THPB-10 (4815).

CONCLUSION

Among these 11 THPB, the 2-hydroxyl-THPB (THPB-143) showed the strongest antagonistic action on D2 receptors.

Authors+Show Affiliations

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10072967

Citation

Wang, L M., et al. "Effects of Tetrahydroprotoberberines On Dopamine D2 Receptors in Ventral Tegmental Area of Rat." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 18, no. 2, 1997, pp. 143-6.
Wang LM, Zhang XX, Jin GZ. Effects of tetrahydroprotoberberines on dopamine D2 receptors in ventral tegmental area of rat. Zhongguo Yao Li Xue Bao. 1997;18(2):143-6.
Wang, L. M., Zhang, X. X., & Jin, G. Z. (1997). Effects of tetrahydroprotoberberines on dopamine D2 receptors in ventral tegmental area of rat. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 18(2), 143-6.
Wang LM, Zhang XX, Jin GZ. Effects of Tetrahydroprotoberberines On Dopamine D2 Receptors in Ventral Tegmental Area of Rat. Zhongguo Yao Li Xue Bao. 1997;18(2):143-6. PubMed PMID: 10072967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of tetrahydroprotoberberines on dopamine D2 receptors in ventral tegmental area of rat. AU - Wang,L M, AU - Zhang,X X, AU - Jin,G Z, PY - 1997/3/1/pubmed PY - 1999/3/12/medline PY - 1997/3/1/entrez SP - 143 EP - 6 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 18 IS - 2 N2 - AIM: To compare the actions of tetrahydroprotoberberines (THPB) on dopamine (DA) D2 receptors in the ventral tegmental area (VTA) of rat. METHODS: Extracellular single unit recording technique was used in i.v. gallamine-paralyzed rats. RESULTS: Eleven THPB analogs tested completely attenuated the apomorphine (Apo, 20 micrograms.kg-1)-induced inhibition on VTA DA cell firing activity. The OH group on C2 at THPB was linked with the reversal of Apo-induced inhibition. Their reversal potencies (ED50, microgram.kg-1) for D2 receptors were: THPB-143 (5.6) > SPD (8.5) > Iso (17.0) > THP (33) > THB (48) > THPB-18 (66) > THPB-1 (179) > THPB-19 (408) > THPB-126 (510) > THPB-104 (1019) > THPB-10 (4815). CONCLUSION: Among these 11 THPB, the 2-hydroxyl-THPB (THPB-143) showed the strongest antagonistic action on D2 receptors. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/10072967/Effects_of_tetrahydroprotoberberines_on_dopamine_D2_receptors_in_ventral_tegmental_area_of_rat_ L2 - http://www.chinaphar.com/1671-4083/18/143.pdf DB - PRIME DP - Unbound Medicine ER -