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Antifungal and antibacterial metabolites from a sclerotium-colonizing isolate of Mortierella vinacea.
J Nat Prod. 1999 Feb; 62(2):386-8.JN

Abstract

The known compound methyl 2,4-dihydroxy-3,5,6-trimethylbenzoate (1) and three new related metabolites, which we have named mortivinacins A (2), B (3), and C (4), were identified as metabolites of the fungus Mortierella vinacea. Nicotinic acid (5) was also encountered. This isolate of M. vinacea was obtained from an Aspergillus flavus sclerotium during field studies of sclerotium longevity in soil. Compounds 1-5 were isolated by chromatographic fractionation of organic extracts from M. vinacea solid-substrate fermentation cultures, and the structures were assigned by analysis of NMR and MS data. Compounds 1, 2, and 5 were responsible for the antibacterial and antifungal activities of the extract.

Authors+Show Affiliations

Soman AG
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Gloer JB
No affiliation info available
Wicklow DT
No affiliation info available

MeSH

Anti-Bacterial AgentsAnti-Infective AgentsAntifungal AgentsAspergillus flavusBacillus subtilisMagnetic Resonance SpectroscopyMass SpectrometryMicrobial Sensitivity TestsMolecular StructureMortierellaStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

10075797

Citation

Soman, A G., et al. "Antifungal and Antibacterial Metabolites From a Sclerotium-colonizing Isolate of Mortierella Vinacea." Journal of Natural Products, vol. 62, no. 2, 1999, pp. 386-8.
Soman AG, Gloer JB, Wicklow DT. Antifungal and antibacterial metabolites from a sclerotium-colonizing isolate of Mortierella vinacea. J Nat Prod. 1999;62(2):386-8.
Soman, A. G., Gloer, J. B., & Wicklow, D. T. (1999). Antifungal and antibacterial metabolites from a sclerotium-colonizing isolate of Mortierella vinacea. Journal of Natural Products, 62(2), 386-8.
Soman AG, Gloer JB, Wicklow DT. Antifungal and Antibacterial Metabolites From a Sclerotium-colonizing Isolate of Mortierella Vinacea. J Nat Prod. 1999;62(2):386-8. PubMed PMID: 10075797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal and antibacterial metabolites from a sclerotium-colonizing isolate of Mortierella vinacea. AU - Soman,A G, AU - Gloer,J B, AU - Wicklow,D T, PY - 1999/3/17/pubmed PY - 1999/3/17/medline PY - 1999/3/17/entrez SP - 386 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 62 IS - 2 N2 - The known compound methyl 2,4-dihydroxy-3,5,6-trimethylbenzoate (1) and three new related metabolites, which we have named mortivinacins A (2), B (3), and C (4), were identified as metabolites of the fungus Mortierella vinacea. Nicotinic acid (5) was also encountered. This isolate of M. vinacea was obtained from an Aspergillus flavus sclerotium during field studies of sclerotium longevity in soil. Compounds 1-5 were isolated by chromatographic fractionation of organic extracts from M. vinacea solid-substrate fermentation cultures, and the structures were assigned by analysis of NMR and MS data. Compounds 1, 2, and 5 were responsible for the antibacterial and antifungal activities of the extract. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/10075797/Antifungal_and_antibacterial_metabolites_from_a_sclerotium_colonizing_isolate_of_Mortierella_vinacea_ DB - PRIME DP - Unbound Medicine ER -