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Cushing's syndrome due to ectopic adrenocorticotropic hormone production by a non-metastatic gastrinoma after long-term conservative treatment of Zollinger-Ellison syndrome.
Ital J Gastroenterol Hepatol. 1998 Dec; 30(6):636-40.IJ

Abstract

This report concerns a case of a Cushing's syndrome 10 years after first diagnosis of a Zollinger-Ellison syndrome within the same patient. In a 69-year-old female patient symptoms of hypergastrinaemia have been successfully treated with a proton pump inhibitor. Cushing's syndrome was the result of ectopic adrenocorticotropic hormone production by a large cystic gastrin-producing tumour of the pancreatic tail. After resection by subtotal pancreatectomy serum adrenocorticotropic hormone, cortisol, gastrin levels and secretin infusion test returned to normal. In contrast to all other previously published cases of ectopic adrenocorticotropic hormone syndrome associated with Zollinger-Ellison syndrome, this tumour had not metastasized into the liver and did not show local invasive growth.

Authors+Show Affiliations

Department of Gastroenterology and Endocrinology, University of Göttingen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10076790

Citation

Raddatz, D, et al. "Cushing's Syndrome Due to Ectopic Adrenocorticotropic Hormone Production By a Non-metastatic Gastrinoma After Long-term Conservative Treatment of Zollinger-Ellison Syndrome." Italian Journal of Gastroenterology and Hepatology, vol. 30, no. 6, 1998, pp. 636-40.
Raddatz D, Horstmann O, Basenau D, et al. Cushing's syndrome due to ectopic adrenocorticotropic hormone production by a non-metastatic gastrinoma after long-term conservative treatment of Zollinger-Ellison syndrome. Ital J Gastroenterol Hepatol. 1998;30(6):636-40.
Raddatz, D., Horstmann, O., Basenau, D., Becker, H., & Ramadori, G. (1998). Cushing's syndrome due to ectopic adrenocorticotropic hormone production by a non-metastatic gastrinoma after long-term conservative treatment of Zollinger-Ellison syndrome. Italian Journal of Gastroenterology and Hepatology, 30(6), 636-40.
Raddatz D, et al. Cushing's Syndrome Due to Ectopic Adrenocorticotropic Hormone Production By a Non-metastatic Gastrinoma After Long-term Conservative Treatment of Zollinger-Ellison Syndrome. Ital J Gastroenterol Hepatol. 1998;30(6):636-40. PubMed PMID: 10076790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cushing's syndrome due to ectopic adrenocorticotropic hormone production by a non-metastatic gastrinoma after long-term conservative treatment of Zollinger-Ellison syndrome. AU - Raddatz,D, AU - Horstmann,O, AU - Basenau,D, AU - Becker,H, AU - Ramadori,G, PY - 1999/3/17/pubmed PY - 1999/3/17/medline PY - 1999/3/17/entrez SP - 636 EP - 40 JF - Italian journal of gastroenterology and hepatology JO - Ital J Gastroenterol Hepatol VL - 30 IS - 6 N2 - This report concerns a case of a Cushing's syndrome 10 years after first diagnosis of a Zollinger-Ellison syndrome within the same patient. In a 69-year-old female patient symptoms of hypergastrinaemia have been successfully treated with a proton pump inhibitor. Cushing's syndrome was the result of ectopic adrenocorticotropic hormone production by a large cystic gastrin-producing tumour of the pancreatic tail. After resection by subtotal pancreatectomy serum adrenocorticotropic hormone, cortisol, gastrin levels and secretin infusion test returned to normal. In contrast to all other previously published cases of ectopic adrenocorticotropic hormone syndrome associated with Zollinger-Ellison syndrome, this tumour had not metastasized into the liver and did not show local invasive growth. SN - 1125-8055 UR - https://www.unboundmedicine.com/medline/citation/10076790/Cushing's_syndrome_due_to_ectopic_adrenocorticotropic_hormone_production_by_a_non_metastatic_gastrinoma_after_long_term_conservative_treatment_of_Zollinger_Ellison_syndrome_ DB - PRIME DP - Unbound Medicine ER -