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Serum interleukin-6 in renal osteodystrophy: relationship with serum PTH and bone remodeling markers.
Horm Metab Res. 1999 Jan; 31(1):14-7.HM

Abstract

Interleukin-6, synthesized by osteoblasts in response to PTH, stimulates osteoclastogenesis and bone resorption in vitro, and it has been implicated in the pathogenesis of bone loss in several clinical situations. The aim of this study was to evaluate whether serum levels of interleukin-6 were increased in patients with renal osteodystrophy, and to investigate the possible relationships between serum interleukin-6 and PTH levels on one hand, and serum interleukin-6 and bone remodeling markers on the other. Serum interleukin-6 (IL-6), intact PTH, osteocalcin, bone alkaline phosphatase (BAP) and carboxyterminal telopeptide of Type 1 collagen (ICTP) were measured in 86 uremic patients. IL-6 (median [range] 16.5 [1.0-430] pg/ml), PTH (279.8 [11-2004] pg/ml), osteocalcin (143.8 [8-921] ng/ml), BAP (20.9 [6-169] U/I) and ICTP (38.8 [1.5-181.5] microg/l) were higher than normal. IL-6 levels correlated with PTH (r= 0.22, p = 0.04) and with ICTP (r = 0.31, p = 0.004). A stronger correlation was found between PTH and circulating bone remodeling markers (r = 0.66 for osteocalcin, r = 0.56 for BAP, and r = 0.39 for ICTP). The correlation between PTH and IL-6 was stronger in those patients (n = 15) with severe secondary hyperparathyroidism (r= 0,71, p = 0.003). On the other hand, in the group of patients (n = 41) with PTH lower than 250 pg/ml, there was no correlation between IL-6 and PTH, while IL-6 correlated with ICTP (r = 0.44, p = 0.006). Serum IL-6 correlates with ICTP which suggests that it may mediate bone resorption in renal osteodystrophy.

Authors+Show Affiliations

Endocrinology Unit, University Hospital Marqués de Valdecilla, Santander, Spain. amadoja@galeno.medi.unican.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10077343

Citation

Montalbán, C, et al. "Serum Interleukin-6 in Renal Osteodystrophy: Relationship With Serum PTH and Bone Remodeling Markers." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 31, no. 1, 1999, pp. 14-7.
Montalbán C, García-Unzueta MT, De Francisco AL, et al. Serum interleukin-6 in renal osteodystrophy: relationship with serum PTH and bone remodeling markers. Horm Metab Res. 1999;31(1):14-7.
Montalbán, C., García-Unzueta, M. T., De Francisco, A. L., & Amado, J. A. (1999). Serum interleukin-6 in renal osteodystrophy: relationship with serum PTH and bone remodeling markers. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 31(1), 14-7.
Montalbán C, et al. Serum Interleukin-6 in Renal Osteodystrophy: Relationship With Serum PTH and Bone Remodeling Markers. Horm Metab Res. 1999;31(1):14-7. PubMed PMID: 10077343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum interleukin-6 in renal osteodystrophy: relationship with serum PTH and bone remodeling markers. AU - Montalbán,C, AU - García-Unzueta,M T, AU - De Francisco,A L, AU - Amado,J A, PY - 1999/3/17/pubmed PY - 1999/3/17/medline PY - 1999/3/17/entrez SP - 14 EP - 7 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 31 IS - 1 N2 - Interleukin-6, synthesized by osteoblasts in response to PTH, stimulates osteoclastogenesis and bone resorption in vitro, and it has been implicated in the pathogenesis of bone loss in several clinical situations. The aim of this study was to evaluate whether serum levels of interleukin-6 were increased in patients with renal osteodystrophy, and to investigate the possible relationships between serum interleukin-6 and PTH levels on one hand, and serum interleukin-6 and bone remodeling markers on the other. Serum interleukin-6 (IL-6), intact PTH, osteocalcin, bone alkaline phosphatase (BAP) and carboxyterminal telopeptide of Type 1 collagen (ICTP) were measured in 86 uremic patients. IL-6 (median [range] 16.5 [1.0-430] pg/ml), PTH (279.8 [11-2004] pg/ml), osteocalcin (143.8 [8-921] ng/ml), BAP (20.9 [6-169] U/I) and ICTP (38.8 [1.5-181.5] microg/l) were higher than normal. IL-6 levels correlated with PTH (r= 0.22, p = 0.04) and with ICTP (r = 0.31, p = 0.004). A stronger correlation was found between PTH and circulating bone remodeling markers (r = 0.66 for osteocalcin, r = 0.56 for BAP, and r = 0.39 for ICTP). The correlation between PTH and IL-6 was stronger in those patients (n = 15) with severe secondary hyperparathyroidism (r= 0,71, p = 0.003). On the other hand, in the group of patients (n = 41) with PTH lower than 250 pg/ml, there was no correlation between IL-6 and PTH, while IL-6 correlated with ICTP (r = 0.44, p = 0.006). Serum IL-6 correlates with ICTP which suggests that it may mediate bone resorption in renal osteodystrophy. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/10077343/Serum_interleukin_6_in_renal_osteodystrophy:_relationship_with_serum_PTH_and_bone_remodeling_markers_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-978689 DB - PRIME DP - Unbound Medicine ER -