TY - JOUR T1 - Development of a flow-transformed pulsatile total artificial heart for total implantation. AU - Imachi,K, AU - Chinzei,T, AU - Abe,Y, AU - Mabuchi,K, AU - Imanishi,K, AU - Yonezawa,T, AU - Suzuki,A, AU - Isoyama,T, AU - Atsumi,K, AU - Fujimasa,I, PY - 1992/6/1/pubmed PY - 1999/3/17/medline PY - 1992/6/1/entrez SP - 308 EP - 13 JF - Artificial organs JO - Artif Organs VL - 16 IS - 3 N2 - To realize a totally implantable total artificial heart (TAH), a new pulsatile TAH, the flow-transformed pulsatile TAH (FTPTAH), was developed. The system was composed of a single centrifugal pump (CFP) and two three-way valves. One port of each three-way valve was connected to the inlet and outlet of a CFP. The other two ports of each valve were connected to the right and left atrium, and the pulmonary artery and aorta. The CFP can perfuse the pulmonary and systemic circulation alternately with pulsatile flow by switching the two three-way valves. A prototype and the secondary model in which the solenoid valves and a spool valve were included, respectively, were connected to a mock circulatory unit with the results that a pulsatile TAH with physiological flow wave form could be obtained from a single CFP, about 5 L/min of pulsatile output could be obtained alternately on the right and left side by switching the solenoid valves or a spool valve, and flow balance between the right and left could be easily controlled by the switching duration. The system is feasible for a totally implantable TAH because it does not need a compliance chamber and can be miniaturized. SN - 0160-564X UR - https://www.unboundmedicine.com/medline/citation/10078267/Development_of_a_flow_transformed_pulsatile_total_artificial_heart_for_total_implantation_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0160-564X&date=1992&volume=16&issue=3&spage=308 DB - PRIME DP - Unbound Medicine ER -