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[Resistance to chloroquine and cycloguanil of Plasmodium falciparum in patients arriving in France after travel in Africa without chemoprophylaxis].
Bull Soc Pathol Exot. 1998; 91(5 Pt 1-2):490-2.BS

Abstract

The in vitro susceptibility of chloroquine and the genomic profile of dihydrofolate reductase (DHFR) codon 108 was determined against african isolates of P. falciparum (Pf) from imported malaria cases without previous drug intake by an isotopic microtest or PCR + RFLP. Pf resistance to chloroquine or to the DHFR inhibitor was present in 49% and 46% of isolates, respectively. Pf drug resistance was more frequent in permanent than in seasonal malarial transmission areas and chloroquine plus DHFR resistance reached 28% in years 1995-97. Updating the guidelines for the prevention of malaria in travellers to Africa is necessary.

Authors+Show Affiliations

Centre national de référence de la chimiosensibilité du paludisme (CNRCP), Hôpital Bichat Claude Bernard, Paris, France. cnrcp.parasit1@bch.ap-hop-paris.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

10078392

Citation

Le Bras, J, et al. "[Resistance to Chloroquine and Cycloguanil of Plasmodium Falciparum in Patients Arriving in France After Travel in Africa Without Chemoprophylaxis]." Bulletin De La Societe De Pathologie Exotique (1990), vol. 91, no. 5 Pt 1-2, 1998, pp. 490-2.
Le Bras J, Pradines B, di Piazza JP, et al. [Resistance to chloroquine and cycloguanil of Plasmodium falciparum in patients arriving in France after travel in Africa without chemoprophylaxis]. Bull Soc Pathol Exot. 1998;91(5 Pt 1-2):490-2.
Le Bras, J., Pradines, B., di Piazza, J. P., Durand, R., Godineau, N., Bouchaud, O., Roué, R., Marchou, B., Martet, G., Longuet, C., & Parzy, D. (1998). [Resistance to chloroquine and cycloguanil of Plasmodium falciparum in patients arriving in France after travel in Africa without chemoprophylaxis]. Bulletin De La Societe De Pathologie Exotique (1990), 91(5 Pt 1-2), 490-2.
Le Bras J, et al. [Resistance to Chloroquine and Cycloguanil of Plasmodium Falciparum in Patients Arriving in France After Travel in Africa Without Chemoprophylaxis]. Bull Soc Pathol Exot. 1998;91(5 Pt 1-2):490-2. PubMed PMID: 10078392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Resistance to chloroquine and cycloguanil of Plasmodium falciparum in patients arriving in France after travel in Africa without chemoprophylaxis]. AU - Le Bras,J, AU - Pradines,B, AU - di Piazza,J P, AU - Durand,R, AU - Godineau,N, AU - Bouchaud,O, AU - Roué,R, AU - Marchou,B, AU - Martet,G, AU - Longuet,C, AU - Parzy,D, PY - 1999/3/17/pubmed PY - 1999/3/17/medline PY - 1999/3/17/entrez SP - 490 EP - 2 JF - Bulletin de la Societe de pathologie exotique (1990) JO - Bull Soc Pathol Exot VL - 91 IS - 5 Pt 1-2 N2 - The in vitro susceptibility of chloroquine and the genomic profile of dihydrofolate reductase (DHFR) codon 108 was determined against african isolates of P. falciparum (Pf) from imported malaria cases without previous drug intake by an isotopic microtest or PCR + RFLP. Pf resistance to chloroquine or to the DHFR inhibitor was present in 49% and 46% of isolates, respectively. Pf drug resistance was more frequent in permanent than in seasonal malarial transmission areas and chloroquine plus DHFR resistance reached 28% in years 1995-97. Updating the guidelines for the prevention of malaria in travellers to Africa is necessary. SN - 0037-9085 UR - https://www.unboundmedicine.com/medline/citation/10078392/[Resistance_to_chloroquine_and_cycloguanil_of_Plasmodium_falciparum_in_patients_arriving_in_France_after_travel_in_Africa_without_chemoprophylaxis]_ L2 - https://medlineplus.gov/travelershealth.html DB - PRIME DP - Unbound Medicine ER -