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Glucose concentration in human subcutaneous adipose tissue: comparison between forearm and abdomen.
Exp Clin Endocrinol Diabetes. 1998; 106(6):465-9.EC

Abstract

There is still controversy about the relation between the glucose concentration in the subcutaneous (sc.) adipose tissue and the blood plasma. Depending on the technique applied, the glucose concentration in sc. tissue varies between 50% and 100% of the plasma glucose concentration. In the present study the sc. glucose concentration of forearm and abdomen in seven healthy volunteers was compared with plasma glucose by applying the microdialysis technique with very low flow rates. A microdialysis probe implanted into the subcutaneous tissue of abdomen and forearm was perfused with a flow rate of 1 microl/4 min. The dialysate was sampled in three 2-h-fractions in the fasting state and in one 2-h-fraction during a hyperglycemic clamp (216.9+/-3.4 mg/dl) (mean +/- SEM). The mean recoveries of the plasma glucose were 91.1+/-4.1% in the forearm and 82.7+/-18.0% in the abdomen. The recoveries in the sc. tissue of abdomen and arm were not significantly different. However, the arm showed significantly (p < 0.014) less interindividual variance (range 73.2- 103.2%) than the abdomen (range 50.6-117.1%) and appears to be the preferable implantation site. The recovery remained constant during the investigation.

Authors+Show Affiliations

Department of Internal Medicine I, University of Lübeck, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10079025

Citation

Thomas, K, et al. "Glucose Concentration in Human Subcutaneous Adipose Tissue: Comparison Between Forearm and Abdomen." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 106, no. 6, 1998, pp. 465-9.
Thomas K, Kiwit M, Kerner W. Glucose concentration in human subcutaneous adipose tissue: comparison between forearm and abdomen. Exp Clin Endocrinol Diabetes. 1998;106(6):465-9.
Thomas, K., Kiwit, M., & Kerner, W. (1998). Glucose concentration in human subcutaneous adipose tissue: comparison between forearm and abdomen. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 106(6), 465-9.
Thomas K, Kiwit M, Kerner W. Glucose Concentration in Human Subcutaneous Adipose Tissue: Comparison Between Forearm and Abdomen. Exp Clin Endocrinol Diabetes. 1998;106(6):465-9. PubMed PMID: 10079025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucose concentration in human subcutaneous adipose tissue: comparison between forearm and abdomen. AU - Thomas,K, AU - Kiwit,M, AU - Kerner,W, PY - 1999/3/17/pubmed PY - 1999/3/17/medline PY - 1999/3/17/entrez SP - 465 EP - 9 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp Clin Endocrinol Diabetes VL - 106 IS - 6 N2 - There is still controversy about the relation between the glucose concentration in the subcutaneous (sc.) adipose tissue and the blood plasma. Depending on the technique applied, the glucose concentration in sc. tissue varies between 50% and 100% of the plasma glucose concentration. In the present study the sc. glucose concentration of forearm and abdomen in seven healthy volunteers was compared with plasma glucose by applying the microdialysis technique with very low flow rates. A microdialysis probe implanted into the subcutaneous tissue of abdomen and forearm was perfused with a flow rate of 1 microl/4 min. The dialysate was sampled in three 2-h-fractions in the fasting state and in one 2-h-fraction during a hyperglycemic clamp (216.9+/-3.4 mg/dl) (mean +/- SEM). The mean recoveries of the plasma glucose were 91.1+/-4.1% in the forearm and 82.7+/-18.0% in the abdomen. The recoveries in the sc. tissue of abdomen and arm were not significantly different. However, the arm showed significantly (p < 0.014) less interindividual variance (range 73.2- 103.2%) than the abdomen (range 50.6-117.1%) and appears to be the preferable implantation site. The recovery remained constant during the investigation. SN - 0947-7349 UR - https://www.unboundmedicine.com/medline/citation/10079025/Glucose_concentration_in_human_subcutaneous_adipose_tissue:_comparison_between_forearm_and_abdomen_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1212017 DB - PRIME DP - Unbound Medicine ER -