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The effect of presynaptic catecholamine depletion on 6-hydroxymelatonin sulfate: a double blind study of alpha-methyl-para-tyrosine.
Eur Neuropsychopharmacol 1999; 9(1-2):61-6EN

Abstract

Because it is a competitive inhibitor of tyrosine hydroxylase, alpha-methyl-para-tyrosine (AMPT) is used to study psychiatric disorders. Melatonin serves as a biological marker of catecholamine function since its secretion is regulated by noradrenergic neurons via beta-adrenergic receptors in the pineal gland. Ten healthy volunteers were administered AMPT in a double-blind placebo controlled study. When subjects received AMPT, nocturnal 6-hydroxymelatonin sulfate (6-SM) decreased significantly as compared with promethazine (night 1 P=0.002; and night 2 P=0.001). Urinary MHPG also decreased on both study days (DF1,9 F=9.82, GG=0.0121). Nocturnal 6-SM excretion and melatonin secretion correlated highly (r=0.91, P=0.0007). Behavioral ratings did not reveal a difference in symptomatology and did not correlate with changes in 6-SM or MHPG. This study demonstrates in healthy controls that 6-SM reliably reflects presynaptic catecholamine depletion induced by AMPT without the emergence of behavioral symptoms.

Authors+Show Affiliations

Department of Psychiatry and Psychology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10082229

Citation

Krahn, L E., et al. "The Effect of Presynaptic Catecholamine Depletion On 6-hydroxymelatonin Sulfate: a Double Blind Study of Alpha-methyl-para-tyrosine." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 9, no. 1-2, 1999, pp. 61-6.
Krahn LE, Lin SC, Klee GG, et al. The effect of presynaptic catecholamine depletion on 6-hydroxymelatonin sulfate: a double blind study of alpha-methyl-para-tyrosine. Eur Neuropsychopharmacol. 1999;9(1-2):61-6.
Krahn, L. E., Lin, S. C., Klee, G. G., Lu, P. Y., Ory, S. J., & Zimmermann, R. C. (1999). The effect of presynaptic catecholamine depletion on 6-hydroxymelatonin sulfate: a double blind study of alpha-methyl-para-tyrosine. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 9(1-2), pp. 61-6.
Krahn LE, et al. The Effect of Presynaptic Catecholamine Depletion On 6-hydroxymelatonin Sulfate: a Double Blind Study of Alpha-methyl-para-tyrosine. Eur Neuropsychopharmacol. 1999;9(1-2):61-6. PubMed PMID: 10082229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of presynaptic catecholamine depletion on 6-hydroxymelatonin sulfate: a double blind study of alpha-methyl-para-tyrosine. AU - Krahn,L E, AU - Lin,S C, AU - Klee,G G, AU - Lu,P Y, AU - Ory,S J, AU - Zimmermann,R C, PY - 1999/3/19/pubmed PY - 1999/3/19/medline PY - 1999/3/19/entrez SP - 61 EP - 6 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 9 IS - 1-2 N2 - Because it is a competitive inhibitor of tyrosine hydroxylase, alpha-methyl-para-tyrosine (AMPT) is used to study psychiatric disorders. Melatonin serves as a biological marker of catecholamine function since its secretion is regulated by noradrenergic neurons via beta-adrenergic receptors in the pineal gland. Ten healthy volunteers were administered AMPT in a double-blind placebo controlled study. When subjects received AMPT, nocturnal 6-hydroxymelatonin sulfate (6-SM) decreased significantly as compared with promethazine (night 1 P=0.002; and night 2 P=0.001). Urinary MHPG also decreased on both study days (DF1,9 F=9.82, GG=0.0121). Nocturnal 6-SM excretion and melatonin secretion correlated highly (r=0.91, P=0.0007). Behavioral ratings did not reveal a difference in symptomatology and did not correlate with changes in 6-SM or MHPG. This study demonstrates in healthy controls that 6-SM reliably reflects presynaptic catecholamine depletion induced by AMPT without the emergence of behavioral symptoms. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/10082229/The_effect_of_presynaptic_catecholamine_depletion_on_6_hydroxymelatonin_sulfate:_a_double_blind_study_of_alpha_methyl_para_tyrosine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(98)00006-6 DB - PRIME DP - Unbound Medicine ER -