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Norepinephrine infused into the basolateral amygdala posttraining enhances retention in a spatial water maze task.
Neurobiol Learn Mem. 1999 Mar; 71(2):232-9.NL

Abstract

Recent evidence indicates that the amygdala plays a role in modulating memory processes in other brain regions. For example, posttraining intra-amygdala infusions of amphetamine enhanced memory in both spatial and cued training water maze tasks; these tasks are known to depend on the integrity of the hippocampus and caudate nucleus, respectively. To determine whether this modulation is dependent on noradrenergic activation within a subregion of the amygdala (the basolateral nucleus), the present study examined the effects of posttraining microinfusions (0.2 microl) of norepinephrine or propranolol into the basolateral amygdala immediately following training in a spatial version of the water maze task. Rats received a four-trial training session on each of 2 consecutive days. On the third day, rats were given a 60-s probe test in the absence of a platform. Retention latencies obtained on the second training day revealed that norepinephrine dose-dependently enhanced retention for the location of the hidden platform. In contrast, propranolol significantly impaired retention. Probe trial analysis revealed that rats treated with 0.25 microg norepinephrine demonstrated a selective spatial bias for the training platform location relative to all other groups. These findings are consistent with others and support the view that the basolateral amygdala has a role in modulating memory storage by interacting with other brain regions.

Authors+Show Affiliations

Department of Psycholobiology, University of California, Irvine California, 92697-3800, USA. hatfield@darwin.bio.uci.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10082642

Citation

Hatfield, T, and J L. McGaugh. "Norepinephrine Infused Into the Basolateral Amygdala Posttraining Enhances Retention in a Spatial Water Maze Task." Neurobiology of Learning and Memory, vol. 71, no. 2, 1999, pp. 232-9.
Hatfield T, McGaugh JL. Norepinephrine infused into the basolateral amygdala posttraining enhances retention in a spatial water maze task. Neurobiol Learn Mem. 1999;71(2):232-9.
Hatfield, T., & McGaugh, J. L. (1999). Norepinephrine infused into the basolateral amygdala posttraining enhances retention in a spatial water maze task. Neurobiology of Learning and Memory, 71(2), 232-9.
Hatfield T, McGaugh JL. Norepinephrine Infused Into the Basolateral Amygdala Posttraining Enhances Retention in a Spatial Water Maze Task. Neurobiol Learn Mem. 1999;71(2):232-9. PubMed PMID: 10082642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Norepinephrine infused into the basolateral amygdala posttraining enhances retention in a spatial water maze task. AU - Hatfield,T, AU - McGaugh,J L, PY - 1999/3/20/pubmed PY - 1999/3/20/medline PY - 1999/3/20/entrez SP - 232 EP - 9 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 71 IS - 2 N2 - Recent evidence indicates that the amygdala plays a role in modulating memory processes in other brain regions. For example, posttraining intra-amygdala infusions of amphetamine enhanced memory in both spatial and cued training water maze tasks; these tasks are known to depend on the integrity of the hippocampus and caudate nucleus, respectively. To determine whether this modulation is dependent on noradrenergic activation within a subregion of the amygdala (the basolateral nucleus), the present study examined the effects of posttraining microinfusions (0.2 microl) of norepinephrine or propranolol into the basolateral amygdala immediately following training in a spatial version of the water maze task. Rats received a four-trial training session on each of 2 consecutive days. On the third day, rats were given a 60-s probe test in the absence of a platform. Retention latencies obtained on the second training day revealed that norepinephrine dose-dependently enhanced retention for the location of the hidden platform. In contrast, propranolol significantly impaired retention. Probe trial analysis revealed that rats treated with 0.25 microg norepinephrine demonstrated a selective spatial bias for the training platform location relative to all other groups. These findings are consistent with others and support the view that the basolateral amygdala has a role in modulating memory storage by interacting with other brain regions. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/10082642/Norepinephrine_infused_into_the_basolateral_amygdala_posttraining_enhances_retention_in_a_spatial_water_maze_task_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(98)93875-8 DB - PRIME DP - Unbound Medicine ER -