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Involvement of the posteroventral caudate-putamen in memory consolidation in the Morris water maze.
Neurobiol Learn Mem. 1999 Mar; 71(2):240-7.NL

Abstract

Male Sprague-Dawley rats implanted with bilateral intracerebral guide cannulae were trained in the standard hidden platform version of the Morris water maze and given immediate posttraining infusions of the D2 dopamine receptor antagonist sulpiride (10.0 or 100.0 ng/side) or saline vehicle into the posteroventral caudate-putamen. Retention was tested 2 days later with a probe trial. Sulpiride-treated rats spent less time swimming near the trained platform location and more time in the periphery of the maze than controls, although their latency to reach the trained platform location was not significantly affected. The pattern of results suggests that whereas the posteroventral caudate-putamen seems to be involved in consolidation of memory in the Morris water maze, it may be involved in memory for procedural aspects of the task in a manner distinct from that of other brain regions such as the hippocampus.

Authors+Show Affiliations

Department of Psychobiology, University of California, Irvine, Irvine California, 92697-3800, USA. bsetlow@ren.psy.jhu.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10082643

Citation

Setlow, B, and J L. McGaugh. "Involvement of the Posteroventral Caudate-putamen in Memory Consolidation in the Morris Water Maze." Neurobiology of Learning and Memory, vol. 71, no. 2, 1999, pp. 240-7.
Setlow B, McGaugh JL. Involvement of the posteroventral caudate-putamen in memory consolidation in the Morris water maze. Neurobiol Learn Mem. 1999;71(2):240-7.
Setlow, B., & McGaugh, J. L. (1999). Involvement of the posteroventral caudate-putamen in memory consolidation in the Morris water maze. Neurobiology of Learning and Memory, 71(2), 240-7.
Setlow B, McGaugh JL. Involvement of the Posteroventral Caudate-putamen in Memory Consolidation in the Morris Water Maze. Neurobiol Learn Mem. 1999;71(2):240-7. PubMed PMID: 10082643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of the posteroventral caudate-putamen in memory consolidation in the Morris water maze. AU - Setlow,B, AU - McGaugh,J L, PY - 1999/3/20/pubmed PY - 1999/3/20/medline PY - 1999/3/20/entrez SP - 240 EP - 7 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 71 IS - 2 N2 - Male Sprague-Dawley rats implanted with bilateral intracerebral guide cannulae were trained in the standard hidden platform version of the Morris water maze and given immediate posttraining infusions of the D2 dopamine receptor antagonist sulpiride (10.0 or 100.0 ng/side) or saline vehicle into the posteroventral caudate-putamen. Retention was tested 2 days later with a probe trial. Sulpiride-treated rats spent less time swimming near the trained platform location and more time in the periphery of the maze than controls, although their latency to reach the trained platform location was not significantly affected. The pattern of results suggests that whereas the posteroventral caudate-putamen seems to be involved in consolidation of memory in the Morris water maze, it may be involved in memory for procedural aspects of the task in a manner distinct from that of other brain regions such as the hippocampus. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/10082643/Involvement_of_the_posteroventral_caudate_putamen_in_memory_consolidation_in_the_Morris_water_maze_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(98)93874-6 DB - PRIME DP - Unbound Medicine ER -