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[The effects of arterial hypertension during pregnancy on birth weight, intrauterine growth retardation and neonatal evolution. A matched case-control study].
An Esp Pediatr 1999; 50(1):52-6AE

Abstract

OBJECTIVE

To determine the impact of hypertensive disorders in pregnancy on birth weight, small-for-gestational age births (SGA) and neonatal outcome.

DESIGN

Matched case-control study.

SETTING

A Tertiary Neonatal Intensive Care Unit.

POPULATION AND METHODS

The effects of maternal hypertension were analyzed in 11,358 infants born between January 1990 and December 1996 at the Italian Hospital of Buenos Aires. Infants born to mothers with pregnancy-induced hypertension, preeclampsia or eclampsia were included. Each infant was matched for gestational age to 1 control infant born to normotensive mothers. Exclusion criteria were: twins, intrauterine infections, chronic hypertension and major malformations.

MAIN OUTCOME MEASURES

Birth weight, incidence of SGA infants, neonatal outcome.

RESULTS

279 infants of hypertensive mothers and 279 controls met the inclusion/exclusion criteria and were enrolled. Maternal hypertension was significantly associated with a higher rate of C-section (OR = 3.80; 95% CI: 2.64-5.50); SGA infants (OR = 7.08; 95% CI: 3.07-18.6), low birth weight (LBW) (OR = 1.8, 95% CI: 1.24-2.60) and very low birth weight infants (VLBW) (OR = 2.14; 95% CI: 1.13-4.19). The frequency of low Apgar score at 5 minutes (OR = 3.63; 95% CI: 1.12-15.3), necrotizing enterocolitis (OR = 3.33; 95% CI: 1.23-10.30) and polycythemia (OR = 3.63; 95% CI: 1.12-15.3) was significantly increased in infants born to hypertensive mothers. There were no significant differences regarding other causes of neonatal morbidity and mortality rate.

CONCLUSIONS

Hypertension in pregnancy mainly increased the risk of SGA infants. Furthermore, infants of hypertensive mothers had a higher incidence of LBW, VLBW, low Apgar score at 5 minutes, necrotizing enterocolitis and polycythemia.

Authors+Show Affiliations

Departamento de Pediatría, Hospital Italiano de Buenos Aires, Argentina.No affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

spa

PubMed ID

10083644

Citation

Fernández Jonusas, S, and J M. Ceriani Cernadas. "[The Effects of Arterial Hypertension During Pregnancy On Birth Weight, Intrauterine Growth Retardation and Neonatal Evolution. a Matched Case-control Study]." Anales Espanoles De Pediatria, vol. 50, no. 1, 1999, pp. 52-6.
Fernández Jonusas S, Ceriani Cernadas JM. [The effects of arterial hypertension during pregnancy on birth weight, intrauterine growth retardation and neonatal evolution. A matched case-control study]. An Esp Pediatr. 1999;50(1):52-6.
Fernández Jonusas, S., & Ceriani Cernadas, J. M. (1999). [The effects of arterial hypertension during pregnancy on birth weight, intrauterine growth retardation and neonatal evolution. A matched case-control study]. Anales Espanoles De Pediatria, 50(1), pp. 52-6.
Fernández Jonusas S, Ceriani Cernadas JM. [The Effects of Arterial Hypertension During Pregnancy On Birth Weight, Intrauterine Growth Retardation and Neonatal Evolution. a Matched Case-control Study]. An Esp Pediatr. 1999;50(1):52-6. PubMed PMID: 10083644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effects of arterial hypertension during pregnancy on birth weight, intrauterine growth retardation and neonatal evolution. A matched case-control study]. AU - Fernández Jonusas,S, AU - Ceriani Cernadas,J M, PY - 1999/3/20/pubmed PY - 1999/3/20/medline PY - 1999/3/20/entrez SP - 52 EP - 6 JF - Anales espanoles de pediatria JO - An. Esp. Pediatr. VL - 50 IS - 1 N2 - OBJECTIVE: To determine the impact of hypertensive disorders in pregnancy on birth weight, small-for-gestational age births (SGA) and neonatal outcome. DESIGN: Matched case-control study. SETTING: A Tertiary Neonatal Intensive Care Unit. POPULATION AND METHODS: The effects of maternal hypertension were analyzed in 11,358 infants born between January 1990 and December 1996 at the Italian Hospital of Buenos Aires. Infants born to mothers with pregnancy-induced hypertension, preeclampsia or eclampsia were included. Each infant was matched for gestational age to 1 control infant born to normotensive mothers. Exclusion criteria were: twins, intrauterine infections, chronic hypertension and major malformations. MAIN OUTCOME MEASURES: Birth weight, incidence of SGA infants, neonatal outcome. RESULTS: 279 infants of hypertensive mothers and 279 controls met the inclusion/exclusion criteria and were enrolled. Maternal hypertension was significantly associated with a higher rate of C-section (OR = 3.80; 95% CI: 2.64-5.50); SGA infants (OR = 7.08; 95% CI: 3.07-18.6), low birth weight (LBW) (OR = 1.8, 95% CI: 1.24-2.60) and very low birth weight infants (VLBW) (OR = 2.14; 95% CI: 1.13-4.19). The frequency of low Apgar score at 5 minutes (OR = 3.63; 95% CI: 1.12-15.3), necrotizing enterocolitis (OR = 3.33; 95% CI: 1.23-10.30) and polycythemia (OR = 3.63; 95% CI: 1.12-15.3) was significantly increased in infants born to hypertensive mothers. There were no significant differences regarding other causes of neonatal morbidity and mortality rate. CONCLUSIONS: Hypertension in pregnancy mainly increased the risk of SGA infants. Furthermore, infants of hypertensive mothers had a higher incidence of LBW, VLBW, low Apgar score at 5 minutes, necrotizing enterocolitis and polycythemia. SN - 0302-4342 UR - https://www.unboundmedicine.com/medline/citation/10083644/[The_effects_of_arterial_hypertension_during_pregnancy_on_birth_weight_intrauterine_growth_retardation_and_neonatal_evolution__A_matched_case_control_study]_ L2 - http://www.diseaseinfosearch.org/result/5922 DB - PRIME DP - Unbound Medicine ER -