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Fungal prophylaxis by reduction of fungal colonization by oral administration of bovine anti-Candida antibodies in bone marrow transplant recipients.
Bone Marrow Transplant. 1999 Feb; 23(3):283-90.BM

Abstract

Candida overgrowth and invasion constitute a serious threat with a high mortality in BMT recipients. Currently available topical antifungal prophylaxis is largely ineffective, and as resistance to existing, absorbable drugs for systemic use is rapidly developing, new forms of therapy are needed. We investigated the effect of oral treatment of BMT recipients with a bovine immunoglobulin product derived from animals immunized against several Candida species. The natural Candida colonization was first followed in 19 patients to establish the colonization pattern. Half of the patients were found to be colonized prior to transplantation and altogether 72% were colonized at some point during follow-up. Those with a high pre-transplant concentration of Candida in saliva (>100 CFU/ml) remained colonized throughout the BMT treatment period. The therapeutic effect was monitored in two other patient groups. The first group consisted of nine patients, where, due to a low number of primary colonized patients, response in colonized patients was suggestive of a therapeutic effect. In the second group, 10 patients with a high level of colonization (>100 CFU/ml) were given 10 g daily of the product in three divided doses. The results suggest a treatment-related reduction in Candida colonization in a majority (7/10) of patients and one patient became completely negative. As no adverse effects were noted, our findings encourage additional studies in immunocompromised, transplant patients.

Authors+Show Affiliations

Department of Transplantation Surgery, KARO, Karolinska Institute at Huddinge Hospital, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10084261

Citation

Tollemar, J, et al. "Fungal Prophylaxis By Reduction of Fungal Colonization By Oral Administration of Bovine anti-Candida Antibodies in Bone Marrow Transplant Recipients." Bone Marrow Transplantation, vol. 23, no. 3, 1999, pp. 283-90.
Tollemar J, Gross N, Dolgiras N, et al. Fungal prophylaxis by reduction of fungal colonization by oral administration of bovine anti-Candida antibodies in bone marrow transplant recipients. Bone Marrow Transplant. 1999;23(3):283-90.
Tollemar, J., Gross, N., Dolgiras, N., Jarstrand, C., Ringdén, O., & Hammarström, L. (1999). Fungal prophylaxis by reduction of fungal colonization by oral administration of bovine anti-Candida antibodies in bone marrow transplant recipients. Bone Marrow Transplantation, 23(3), 283-90.
Tollemar J, et al. Fungal Prophylaxis By Reduction of Fungal Colonization By Oral Administration of Bovine anti-Candida Antibodies in Bone Marrow Transplant Recipients. Bone Marrow Transplant. 1999;23(3):283-90. PubMed PMID: 10084261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fungal prophylaxis by reduction of fungal colonization by oral administration of bovine anti-Candida antibodies in bone marrow transplant recipients. AU - Tollemar,J, AU - Gross,N, AU - Dolgiras,N, AU - Jarstrand,C, AU - Ringdén,O, AU - Hammarström,L, PY - 1999/3/20/pubmed PY - 1999/3/20/medline PY - 1999/3/20/entrez SP - 283 EP - 90 JF - Bone marrow transplantation JO - Bone Marrow Transplant. VL - 23 IS - 3 N2 - Candida overgrowth and invasion constitute a serious threat with a high mortality in BMT recipients. Currently available topical antifungal prophylaxis is largely ineffective, and as resistance to existing, absorbable drugs for systemic use is rapidly developing, new forms of therapy are needed. We investigated the effect of oral treatment of BMT recipients with a bovine immunoglobulin product derived from animals immunized against several Candida species. The natural Candida colonization was first followed in 19 patients to establish the colonization pattern. Half of the patients were found to be colonized prior to transplantation and altogether 72% were colonized at some point during follow-up. Those with a high pre-transplant concentration of Candida in saliva (>100 CFU/ml) remained colonized throughout the BMT treatment period. The therapeutic effect was monitored in two other patient groups. The first group consisted of nine patients, where, due to a low number of primary colonized patients, response in colonized patients was suggestive of a therapeutic effect. In the second group, 10 patients with a high level of colonization (>100 CFU/ml) were given 10 g daily of the product in three divided doses. The results suggest a treatment-related reduction in Candida colonization in a majority (7/10) of patients and one patient became completely negative. As no adverse effects were noted, our findings encourage additional studies in immunocompromised, transplant patients. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/10084261/Fungal_prophylaxis_by_reduction_of_fungal_colonization_by_oral_administration_of_bovine_anti_Candida_antibodies_in_bone_marrow_transplant_recipients_ L2 - http://dx.doi.org/10.1038/sj.bmt.1701560 DB - PRIME DP - Unbound Medicine ER -