Tags

Type your tag names separated by a space and hit enter

The oxidant/antioxidant network: role of melatonin.
Biol Signals Recept. 1999 Jan-Apr; 8(1-2):56-63.BS

Abstract

Melatonin is now known to be a multifaceted free radical scavenger and antioxidant. It detoxifies a variety of free radicals and reactive oxygen intermediates including the hydroxyl radical, peroxynitrite anion, singlet oxygen and nitric oxide. Additionally, it reportedly stimulates several antioxidative enzymes including glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and superoxide dismutase; conversely, it inhibits a prooxidative enzyme, nitric oxide synthase. Melatonin also crosses all morphophysiological barriers, e.g., the blood-brain barrier, placenta, and distributes throughout the cell; these features increase the efficacy of melatonin as an antioxidant. Melatonin has been shown to markedly protect both membrane lipids and nuclear DNA from oxidative damage. In every experimental model in which melatonin has been tested, it has been found to resist macromolecular damage and the associated dysfunction associated with free radicals.

Authors+Show Affiliations

Reiter RJ
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Tex. 78284-7762, USA.
Tan DX
No affiliation info available
Cabrera J
No affiliation info available
D'Arpa D
No affiliation info available
Sainz RM
No affiliation info available
Mayo JC
No affiliation info available
Ramos S
No affiliation info available

MeSH

AnimalsAntioxidantsFree Radical ScavengersFree RadicalsHumansMelatoninOxidantsPineal GlandReactive Oxygen Species

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10085463

Citation

Reiter, R J., et al. "The Oxidant/antioxidant Network: Role of Melatonin." Biological Signals and Receptors, vol. 8, no. 1-2, 1999, pp. 56-63.
Reiter RJ, Tan DX, Cabrera J, et al. The oxidant/antioxidant network: role of melatonin. Biol Signals Recept. 1999;8(1-2):56-63.
Reiter, R. J., Tan, D. X., Cabrera, J., D'Arpa, D., Sainz, R. M., Mayo, J. C., & Ramos, S. (1999). The oxidant/antioxidant network: role of melatonin. Biological Signals and Receptors, 8(1-2), 56-63.
Reiter RJ, et al. The Oxidant/antioxidant Network: Role of Melatonin. Biol Signals Recept. 1999 Jan-Apr;8(1-2):56-63. PubMed PMID: 10085463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The oxidant/antioxidant network: role of melatonin. AU - Reiter,R J, AU - Tan,D X, AU - Cabrera,J, AU - D'Arpa,D, AU - Sainz,R M, AU - Mayo,J C, AU - Ramos,S, PY - 1999/3/23/pubmed PY - 2000/8/16/medline PY - 1999/3/23/entrez SP - 56 EP - 63 JF - Biological signals and receptors JO - Biol Signals Recept VL - 8 IS - 1-2 N2 - Melatonin is now known to be a multifaceted free radical scavenger and antioxidant. It detoxifies a variety of free radicals and reactive oxygen intermediates including the hydroxyl radical, peroxynitrite anion, singlet oxygen and nitric oxide. Additionally, it reportedly stimulates several antioxidative enzymes including glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and superoxide dismutase; conversely, it inhibits a prooxidative enzyme, nitric oxide synthase. Melatonin also crosses all morphophysiological barriers, e.g., the blood-brain barrier, placenta, and distributes throughout the cell; these features increase the efficacy of melatonin as an antioxidant. Melatonin has been shown to markedly protect both membrane lipids and nuclear DNA from oxidative damage. In every experimental model in which melatonin has been tested, it has been found to resist macromolecular damage and the associated dysfunction associated with free radicals. SN - 1422-4933 UR - https://www.unboundmedicine.com/medline/citation/10085463/The_oxidant/antioxidant_network:_role_of_melatonin_ DB - PRIME DP - Unbound Medicine ER -