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Gender, age, and body weight are the major predictive factors for bone mineral density in Crohn's disease: a case-control cross-sectional study of 113 patients.
Am J Gastroenterol. 1999 Mar; 94(3):824-8.AJ

Abstract

OBJECTIVE

We conducted this study to assess bone mineral density and to evaluate conceivable predictive factors for bone loss in patients with Crohn's disease.

METHODS

One hundred-thirteen patients with Crohn's disease and 113 healthy subjects, individually matched for gender, age, and body weight were investigated. The group consisted of 68 women and 45 men. The median duration of Crohn's disease was 6 yr. Two-thirds of the patients had been subjected to intestinal resection. Seventy-seven percent had at some time been treated with corticosteroids. Bone mineral density in the lumbar spine, the hip, and the total body skeleton was measured by dual-energy X-ray absorptiometry (DEXA).

RESULTS

In patients with Crohn's disease bone mineral density was not different from that of healthy controls except for a regional decrease in bone mineral density of the hip in female patients. The strongest predictors of bone mineral density were gender, age, and body weight. Corticosteroid use was only a weak predictor of diminished bone density. Duration of disease and intestinal resection had no predictive value for bone mineral density.

CONCLUSIONS

Gender, age, and body weight are the major determinants of bone mineral density in patients with Crohn's disease. As in healthy individuals, the combined effect of these factors account for up to 50% of the variability in bone mineral density.

Authors+Show Affiliations

Medical Department C, Roskilde County Hospital Køge, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10086673

Citation

Andreassen, H, et al. "Gender, Age, and Body Weight Are the Major Predictive Factors for Bone Mineral Density in Crohn's Disease: a Case-control Cross-sectional Study of 113 Patients." The American Journal of Gastroenterology, vol. 94, no. 3, 1999, pp. 824-8.
Andreassen H, Hylander E, Rix M. Gender, age, and body weight are the major predictive factors for bone mineral density in Crohn's disease: a case-control cross-sectional study of 113 patients. Am J Gastroenterol. 1999;94(3):824-8.
Andreassen, H., Hylander, E., & Rix, M. (1999). Gender, age, and body weight are the major predictive factors for bone mineral density in Crohn's disease: a case-control cross-sectional study of 113 patients. The American Journal of Gastroenterology, 94(3), 824-8.
Andreassen H, Hylander E, Rix M. Gender, Age, and Body Weight Are the Major Predictive Factors for Bone Mineral Density in Crohn's Disease: a Case-control Cross-sectional Study of 113 Patients. Am J Gastroenterol. 1999;94(3):824-8. PubMed PMID: 10086673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender, age, and body weight are the major predictive factors for bone mineral density in Crohn's disease: a case-control cross-sectional study of 113 patients. AU - Andreassen,H, AU - Hylander,E, AU - Rix,M, PY - 1999/3/23/pubmed PY - 1999/3/23/medline PY - 1999/3/23/entrez SP - 824 EP - 8 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 94 IS - 3 N2 - OBJECTIVE: We conducted this study to assess bone mineral density and to evaluate conceivable predictive factors for bone loss in patients with Crohn's disease. METHODS: One hundred-thirteen patients with Crohn's disease and 113 healthy subjects, individually matched for gender, age, and body weight were investigated. The group consisted of 68 women and 45 men. The median duration of Crohn's disease was 6 yr. Two-thirds of the patients had been subjected to intestinal resection. Seventy-seven percent had at some time been treated with corticosteroids. Bone mineral density in the lumbar spine, the hip, and the total body skeleton was measured by dual-energy X-ray absorptiometry (DEXA). RESULTS: In patients with Crohn's disease bone mineral density was not different from that of healthy controls except for a regional decrease in bone mineral density of the hip in female patients. The strongest predictors of bone mineral density were gender, age, and body weight. Corticosteroid use was only a weak predictor of diminished bone density. Duration of disease and intestinal resection had no predictive value for bone mineral density. CONCLUSIONS: Gender, age, and body weight are the major determinants of bone mineral density in patients with Crohn's disease. As in healthy individuals, the combined effect of these factors account for up to 50% of the variability in bone mineral density. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10086673/Gender_age_and_body_weight_are_the_major_predictive_factors_for_bone_mineral_density_in_Crohn's_disease:_a_case_control_cross_sectional_study_of_113_patients_ L2 - https://Insights.ovid.com/pubmed?pmid=10086673 DB - PRIME DP - Unbound Medicine ER -