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Effect of long-term use of moisturizer on skin hydration, barrier function and susceptibility to irritants.
Acta Derm Venereol. 1999 Jan; 79(1):49-51.AD

Abstract

Moisturizers are often used in the prevention and treatment of irritant contact dermatitis. The present study was to determine whether long-term daily use of a moisturizer on normal skin would affect skin barrier function, hydration state, or susceptibility to sodium lauryl sulphate. Healthy volunteers used a moisturizer on one forearm 3 times daily for 4 weeks. The other forearm served as a control. Afterwards both forearms were challenged with a patch-test of sodium lauryl sulphate. Skin barrier function was evaluated by measuring trans-epidermal water loss and skin hydration by measuring electrical capacitance. Electrical capacitance was significantly increased on the treated arm during the treatment period. After challenge with sodium lauryl sulphate, transepidermal water loss was significantly higher on the arm treated with moisturizer than on the control arm. The results suggest that long-term treatment with moisturizers on normal skin may increase skin susceptibility to irritants.

Authors+Show Affiliations

Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10086859

Citation

Held, E, et al. "Effect of Long-term Use of Moisturizer On Skin Hydration, Barrier Function and Susceptibility to Irritants." Acta Dermato-venereologica, vol. 79, no. 1, 1999, pp. 49-51.
Held E, Sveinsdóttir S, Agner T. Effect of long-term use of moisturizer on skin hydration, barrier function and susceptibility to irritants. Acta Derm Venereol. 1999;79(1):49-51.
Held, E., Sveinsdóttir, S., & Agner, T. (1999). Effect of long-term use of moisturizer on skin hydration, barrier function and susceptibility to irritants. Acta Dermato-venereologica, 79(1), 49-51.
Held E, Sveinsdóttir S, Agner T. Effect of Long-term Use of Moisturizer On Skin Hydration, Barrier Function and Susceptibility to Irritants. Acta Derm Venereol. 1999;79(1):49-51. PubMed PMID: 10086859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of long-term use of moisturizer on skin hydration, barrier function and susceptibility to irritants. AU - Held,E, AU - Sveinsdóttir,S, AU - Agner,T, PY - 1999/3/23/pubmed PY - 1999/3/23/medline PY - 1999/3/23/entrez SP - 49 EP - 51 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 79 IS - 1 N2 - Moisturizers are often used in the prevention and treatment of irritant contact dermatitis. The present study was to determine whether long-term daily use of a moisturizer on normal skin would affect skin barrier function, hydration state, or susceptibility to sodium lauryl sulphate. Healthy volunteers used a moisturizer on one forearm 3 times daily for 4 weeks. The other forearm served as a control. Afterwards both forearms were challenged with a patch-test of sodium lauryl sulphate. Skin barrier function was evaluated by measuring trans-epidermal water loss and skin hydration by measuring electrical capacitance. Electrical capacitance was significantly increased on the treated arm during the treatment period. After challenge with sodium lauryl sulphate, transepidermal water loss was significantly higher on the arm treated with moisturizer than on the control arm. The results suggest that long-term treatment with moisturizers on normal skin may increase skin susceptibility to irritants. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/10086859/Effect_of_long_term_use_of_moisturizer_on_skin_hydration_barrier_function_and_susceptibility_to_irritants_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.1080/000155599750011705 DB - PRIME DP - Unbound Medicine ER -