Prime

Type your tag names separated by a space and hit enter

Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity.

Abstract

Induction of micronuclei and chromosomal aberrations produced by whole body exposure of r-radiation (1.5-3.0 Gy) in mice was found to be significantly inhibited by oral administration of natural antioxidants, curcumin (400 micro moles), ellagic acid (200 micro moles) and bixin (200 micro moles) per kilogram body weight. These antioxidants induced inhibition of micronucleated polychromatic and normochromatic erythrocytes, was comparable with alpha-tocopherol (200 micro moles) administration. Curcumin and ellagic acid were also found to significantly reduce the number of bone marrow cells with chromosomal aberrations and chromosomal fragments as effectively as alpha-tocopherol. Moreover, administration of antioxidants inhibited the DNA strand breaks produced in rat lymphocytes upon radiation as seen from the DNA unwinding studies. These results indicated that antioxidant curcumin, ellagic acid and bixin provide protection against chromosome damage produced by radiation.

Authors

, ,

Source

MeSH

Animals
Bone Marrow Cells
Carotenoids
Chromosome Aberrations
Chromosomes
Curcumin
DNA Damage
Ellagic Acid
Lymphocytes
Male
Mice
Micronuclei, Chromosome-Defective
Mutagenicity Tests
Radiation-Protective Agents
Rats
Rats, Sprague-Dawley

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10089063

Citation

TY - JOUR T1 - Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity. AU - Thresiamma,K C, AU - George,J, AU - Kuttan,R, PY - 1999/3/24/pubmed PY - 1999/3/24/medline PY - 1999/3/24/entrez SP - 431 EP - 4 JF - Journal of experimental & clinical cancer research : CR JO - J. Exp. Clin. Cancer Res. VL - 17 IS - 4 N2 - Induction of micronuclei and chromosomal aberrations produced by whole body exposure of r-radiation (1.5-3.0 Gy) in mice was found to be significantly inhibited by oral administration of natural antioxidants, curcumin (400 micro moles), ellagic acid (200 micro moles) and bixin (200 micro moles) per kilogram body weight. These antioxidants induced inhibition of micronucleated polychromatic and normochromatic erythrocytes, was comparable with alpha-tocopherol (200 micro moles) administration. Curcumin and ellagic acid were also found to significantly reduce the number of bone marrow cells with chromosomal aberrations and chromosomal fragments as effectively as alpha-tocopherol. Moreover, administration of antioxidants inhibited the DNA strand breaks produced in rat lymphocytes upon radiation as seen from the DNA unwinding studies. These results indicated that antioxidant curcumin, ellagic acid and bixin provide protection against chromosome damage produced by radiation. SN - 0392-9078 UR - https://www.unboundmedicine.com/medline/citation/10089063/Protective_effect_of_curcumin_ellagic_acid_and_bixin_on_radiation_induced_genotoxicity_ L2 - http://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+hsdb:@term+@rn+458-37-7 ER -