Tags

Type your tag names separated by a space and hit enter

[Pathological bone density in chronic inflammatory bowel diseases--prevalence and risk factors].
Z Gastroenterol. 1999 Jan; 37(1):5-12.ZG

Abstract

INTRODUCTION

Osteopenia and osteoporosis are frequent but often underestimated complications in inflammatory bowel disease. In patients with IBD, several factors could contribute to osteopenia, but the pathogenetic mechanisms are still not completely understood. We carried out a prospective study to evaluate the prevalence and possible etiologic factors for osteopenia and subsequent osteoporosis in IBD-patients.

METHODS

140 patients with inflammatory bowel disease (Crohn's disease n = 125, ulcerative colitis n = 15) underwent clinical and spine radiological assessments. Lumbar bone mineral densities were measured by dual energy X-ray absorptiometry (DXA). Markers of bone formation and resorption and vitamin D were assessed in n = 95 patients. Patients were asked about medication, previous or actual intestinal stenosis, smoking and intestinal resection. A lactose-H2-breath test was undertaken if lactose intolerance was clinically suspected.

RESULTS

Compared to age- and sex-matched healthy controls (Z-score), the prevalence of osteopenia (Z < -1) was 62%, while osteoporosis (Z < -2) occurred in 38%. The mean bone density of IBD-patients was osteopenic with no significant differences between Crohn's disease (Z = -1.24) and ulcerative colitis (Z = -1.25). Osteoporotic fractures were seen in three patients (2.1%). Crohn's disease patients with osteoporosis showed a significant lower body mass index (BMI) than patients with normal bone density. 52.9% of patients with manifest osteoporosis underwent systemic steroid treatment in the preceding year, but only 34% of those with normal bone density. Except hemoglobin, none of the biochemical markers showed a significant difference between osteoporosis, osteopenia and patients with normal bone density.

CONCLUSION

The results show a high prevalence of osteopenia and osteoporosis in IBD. Since osteoporosis is often associated with low body mass index, multiple intestinal resections and previous systemic steroid treatment, we suggest a bone densitometry in these patients. Since etiology of osteoporosis in IBD is multifactorious and not completely understood, there is still no standard treatment. The effect of osteoanabolic and antiresorptive agents must be evaluated in further studies.

Authors+Show Affiliations

Abteilung Innere Medizin I, Universitätsklinikum Ulm.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

10091278

Citation

Von Tirpitz, C, et al. "[Pathological Bone Density in Chronic Inflammatory Bowel Diseases--prevalence and Risk Factors]." Zeitschrift Fur Gastroenterologie, vol. 37, no. 1, 1999, pp. 5-12.
Von Tirpitz C, Pischulti G, Klaus J, et al. [Pathological bone density in chronic inflammatory bowel diseases--prevalence and risk factors]. Z Gastroenterol. 1999;37(1):5-12.
Von Tirpitz, C., Pischulti, G., Klaus, J., Rieber, A., Brückel, J., Böhm, B. O., Adler, G., & Reinshagen, M. (1999). [Pathological bone density in chronic inflammatory bowel diseases--prevalence and risk factors]. Zeitschrift Fur Gastroenterologie, 37(1), 5-12.
Von Tirpitz C, et al. [Pathological Bone Density in Chronic Inflammatory Bowel Diseases--prevalence and Risk Factors]. Z Gastroenterol. 1999;37(1):5-12. PubMed PMID: 10091278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pathological bone density in chronic inflammatory bowel diseases--prevalence and risk factors]. AU - Von Tirpitz,C, AU - Pischulti,G, AU - Klaus,J, AU - Rieber,A, AU - Brückel,J, AU - Böhm,B O, AU - Adler,G, AU - Reinshagen,M, PY - 1999/3/26/pubmed PY - 1999/3/26/medline PY - 1999/3/26/entrez SP - 5 EP - 12 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 37 IS - 1 N2 - INTRODUCTION: Osteopenia and osteoporosis are frequent but often underestimated complications in inflammatory bowel disease. In patients with IBD, several factors could contribute to osteopenia, but the pathogenetic mechanisms are still not completely understood. We carried out a prospective study to evaluate the prevalence and possible etiologic factors for osteopenia and subsequent osteoporosis in IBD-patients. METHODS: 140 patients with inflammatory bowel disease (Crohn's disease n = 125, ulcerative colitis n = 15) underwent clinical and spine radiological assessments. Lumbar bone mineral densities were measured by dual energy X-ray absorptiometry (DXA). Markers of bone formation and resorption and vitamin D were assessed in n = 95 patients. Patients were asked about medication, previous or actual intestinal stenosis, smoking and intestinal resection. A lactose-H2-breath test was undertaken if lactose intolerance was clinically suspected. RESULTS: Compared to age- and sex-matched healthy controls (Z-score), the prevalence of osteopenia (Z < -1) was 62%, while osteoporosis (Z < -2) occurred in 38%. The mean bone density of IBD-patients was osteopenic with no significant differences between Crohn's disease (Z = -1.24) and ulcerative colitis (Z = -1.25). Osteoporotic fractures were seen in three patients (2.1%). Crohn's disease patients with osteoporosis showed a significant lower body mass index (BMI) than patients with normal bone density. 52.9% of patients with manifest osteoporosis underwent systemic steroid treatment in the preceding year, but only 34% of those with normal bone density. Except hemoglobin, none of the biochemical markers showed a significant difference between osteoporosis, osteopenia and patients with normal bone density. CONCLUSION: The results show a high prevalence of osteopenia and osteoporosis in IBD. Since osteoporosis is often associated with low body mass index, multiple intestinal resections and previous systemic steroid treatment, we suggest a bone densitometry in these patients. Since etiology of osteoporosis in IBD is multifactorious and not completely understood, there is still no standard treatment. The effect of osteoanabolic and antiresorptive agents must be evaluated in further studies. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/10091278/[Pathological_bone_density_in_chronic_inflammatory_bowel_diseases__prevalence_and_risk_factors]_ L2 - https://medlineplus.gov/osteoporosis.html DB - PRIME DP - Unbound Medicine ER -