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Diagnostic utility of Müllerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors.
Gynecol Oncol 1999; 73(1):51-5GO

Abstract

OBJECTIVES

In this study we evaluated changes in serum Müllerian inhibiting substance (MIS) concentration in a large number of patients with granulosa cell tumors (GCT) to determine whether MIS is elevated at the time of presentation and whether MIS is an index of successful surgical resection and management of recurrences.

METHODS

We retrospectively reviewed MIS levels from 17 subjects prior to tumor resection and studied serial MIS samples from 56 subjects following initial tumor resection. Clinical follow-up information was available for 36 of those with postoperative MIS values. Serum MIS was measured by an ELISA. MIS values were compared to a combination of normative values previously established in our laboratory and from more recently obtained samples from older pre- and postmenopausal women, using this assay.

RESULTS

Serum MIS was elevated pre-operatively in 6 of 8 (75%) subjects with juvenile GCTs and in 7 of 9 (78%) of those with adult GCTs relative to age-matched controls (76% for both types combined). Post-operative clinical correlation was available for 36 patients. There was no clinical recurrence in 21 subjects with normal or undetectable postoperative values, and incompletely resectable tumor or recurrence was identified in 6 of 15 patients with elevated postoperative values.

CONCLUSIONS

The results of this study demonstrate that postoperative serum MIS concentrations may be used to evaluate the completeness of tumor removal following initial surgery and that serial MIS determinations may allow the detection of recurrences.

Authors+Show Affiliations

Pediatric Surgical Research Laboratory, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10094880

Citation

Lane, A H., et al. "Diagnostic Utility of Müllerian Inhibiting Substance Determination in Patients With Primary and Recurrent Granulosa Cell Tumors." Gynecologic Oncology, vol. 73, no. 1, 1999, pp. 51-5.
Lane AH, Lee MM, Fuller AF, et al. Diagnostic utility of Müllerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors. Gynecol Oncol. 1999;73(1):51-5.
Lane, A. H., Lee, M. M., Fuller, A. F., Kehas, D. J., Donahoe, P. K., & MacLaughlin, D. T. (1999). Diagnostic utility of Müllerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors. Gynecologic Oncology, 73(1), pp. 51-5.
Lane AH, et al. Diagnostic Utility of Müllerian Inhibiting Substance Determination in Patients With Primary and Recurrent Granulosa Cell Tumors. Gynecol Oncol. 1999;73(1):51-5. PubMed PMID: 10094880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic utility of Müllerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors. AU - Lane,A H, AU - Lee,M M, AU - Fuller,A F,Jr AU - Kehas,D J, AU - Donahoe,P K, AU - MacLaughlin,D T, PY - 1999/3/30/pubmed PY - 2001/3/28/medline PY - 1999/3/30/entrez SP - 51 EP - 5 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 73 IS - 1 N2 - OBJECTIVES: In this study we evaluated changes in serum Müllerian inhibiting substance (MIS) concentration in a large number of patients with granulosa cell tumors (GCT) to determine whether MIS is elevated at the time of presentation and whether MIS is an index of successful surgical resection and management of recurrences. METHODS: We retrospectively reviewed MIS levels from 17 subjects prior to tumor resection and studied serial MIS samples from 56 subjects following initial tumor resection. Clinical follow-up information was available for 36 of those with postoperative MIS values. Serum MIS was measured by an ELISA. MIS values were compared to a combination of normative values previously established in our laboratory and from more recently obtained samples from older pre- and postmenopausal women, using this assay. RESULTS: Serum MIS was elevated pre-operatively in 6 of 8 (75%) subjects with juvenile GCTs and in 7 of 9 (78%) of those with adult GCTs relative to age-matched controls (76% for both types combined). Post-operative clinical correlation was available for 36 patients. There was no clinical recurrence in 21 subjects with normal or undetectable postoperative values, and incompletely resectable tumor or recurrence was identified in 6 of 15 patients with elevated postoperative values. CONCLUSIONS: The results of this study demonstrate that postoperative serum MIS concentrations may be used to evaluate the completeness of tumor removal following initial surgery and that serial MIS determinations may allow the detection of recurrences. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/10094880/Diagnostic_utility_of_Müllerian_inhibiting_substance_determination_in_patients_with_primary_and_recurrent_granulosa_cell_tumors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(98)95290-8 DB - PRIME DP - Unbound Medicine ER -