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Leptin values in placental cord blood of human newborns with normal intrauterine growth after 30-42 weeks of gestation.
Horm Res 1999; 51(1):10-4HR

Abstract

OBJECTIVE

To evaluate leptin values in placental cord blood of newborns with normal intrauterine growth after 30-42 weeks of gestation.

DESIGN

Leptin, a protein encoded by the ob gene, plays an important role in the regulation of feeding behaviour and energy balance in rodents, primates and humans. The presence of leptin in human amniotic fluid and cord blood has recently been reported in human gestations at term and the possible role of leptin in human fetal growth suggested. However, little is known of leptin synthesis during human foetal development. Thus, the aim of our work was to measure leptin (RIA, Linco Research, Inc.) in placental cord blood of human newborns at different fetal ages.

PATIENTS

One hundred and twenty-six healthy newborns with normal intrauterine growth were studied. Twenty-nine were preterm (15 males and 14 females; gestational age: 30-36 weeks) and 99 were at term (49 males and 48 females; gestational age: 37-42 weeks).

RESULTS

Leptin values increase progressively throughout gestation from 1.30 +/- 0.53 ng/ml at 30 weeks of gestation to 7.98 +/- 4.96 ng/ml (mean +/- SD) at term, and correlate positively with birth weight (r = 0.56, p < 0. 005, n = 126), length (r = 0.37, p < 0.005, n = 126), BMI (r = 0.57, p < 0.005, n = 126), head circumference (r = 0.37, p < 0.005, n = 126), gestational age (r = 0.48, p < 0.005, n = 126) and placental weight (r = 0.38, p < 0.003, n = 59). Leptin values are statistically significantly lower (p < 0.005) preterm (median: 2.05 ng/ml; range: 0.7-8.3 ng/ml) than at term (median: 7.0 ng/ml; range: 1.1-28.1 ng/ml). Leptin values are also significantly (p < 0.005) higher in females (median: 7.2 ng/ml; range: 0.9-23.6 ng/ml, n = 62) than in males (median: 4.8 ng/ml; range: 0.7-28.1 ng/ml, n = 64), although there are no differences in weight (2,864 +/- 536 g in females vs. 2,937 +/- 744 g in males). Multiple regression analysis shows weight to be a positive sex-independent predictor of serum leptin values (p < 0.0005). Sex also proves to be a predictor of leptin, independently of weight and is higher in females than in males (p < 0.003).

CONCLUSION

Leptin is present in placental human cord blood after 30-42 weeks of gestation. Newborn weight and sex are independent predictors of leptin values.

Authors+Show Affiliations

Department of Pediatrics, Endocrine and Hormone Laboratory Units, Autonomous University, Children's Hospital Vall d'Hebron, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10095163

Citation

Gómez, L, et al. "Leptin Values in Placental Cord Blood of Human Newborns With Normal Intrauterine Growth After 30-42 Weeks of Gestation." Hormone Research, vol. 51, no. 1, 1999, pp. 10-4.
Gómez L, Carrascosa A, Yeste D, et al. Leptin values in placental cord blood of human newborns with normal intrauterine growth after 30-42 weeks of gestation. Horm Res. 1999;51(1):10-4.
Gómez, L., Carrascosa, A., Yeste, D., Potau, N., Riqué, S., Ruiz-Cuevas, P., & Almar, J. (1999). Leptin values in placental cord blood of human newborns with normal intrauterine growth after 30-42 weeks of gestation. Hormone Research, 51(1), pp. 10-4.
Gómez L, et al. Leptin Values in Placental Cord Blood of Human Newborns With Normal Intrauterine Growth After 30-42 Weeks of Gestation. Horm Res. 1999;51(1):10-4. PubMed PMID: 10095163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptin values in placental cord blood of human newborns with normal intrauterine growth after 30-42 weeks of gestation. AU - Gómez,L, AU - Carrascosa,A, AU - Yeste,D, AU - Potau,N, AU - Riqué,S, AU - Ruiz-Cuevas,P, AU - Almar,J, PY - 1999/3/30/pubmed PY - 2000/8/16/medline PY - 1999/3/30/entrez SP - 10 EP - 4 JF - Hormone research JO - Horm. Res. VL - 51 IS - 1 N2 - OBJECTIVE: To evaluate leptin values in placental cord blood of newborns with normal intrauterine growth after 30-42 weeks of gestation. DESIGN: Leptin, a protein encoded by the ob gene, plays an important role in the regulation of feeding behaviour and energy balance in rodents, primates and humans. The presence of leptin in human amniotic fluid and cord blood has recently been reported in human gestations at term and the possible role of leptin in human fetal growth suggested. However, little is known of leptin synthesis during human foetal development. Thus, the aim of our work was to measure leptin (RIA, Linco Research, Inc.) in placental cord blood of human newborns at different fetal ages. PATIENTS: One hundred and twenty-six healthy newborns with normal intrauterine growth were studied. Twenty-nine were preterm (15 males and 14 females; gestational age: 30-36 weeks) and 99 were at term (49 males and 48 females; gestational age: 37-42 weeks). RESULTS: Leptin values increase progressively throughout gestation from 1.30 +/- 0.53 ng/ml at 30 weeks of gestation to 7.98 +/- 4.96 ng/ml (mean +/- SD) at term, and correlate positively with birth weight (r = 0.56, p < 0. 005, n = 126), length (r = 0.37, p < 0.005, n = 126), BMI (r = 0.57, p < 0.005, n = 126), head circumference (r = 0.37, p < 0.005, n = 126), gestational age (r = 0.48, p < 0.005, n = 126) and placental weight (r = 0.38, p < 0.003, n = 59). Leptin values are statistically significantly lower (p < 0.005) preterm (median: 2.05 ng/ml; range: 0.7-8.3 ng/ml) than at term (median: 7.0 ng/ml; range: 1.1-28.1 ng/ml). Leptin values are also significantly (p < 0.005) higher in females (median: 7.2 ng/ml; range: 0.9-23.6 ng/ml, n = 62) than in males (median: 4.8 ng/ml; range: 0.7-28.1 ng/ml, n = 64), although there are no differences in weight (2,864 +/- 536 g in females vs. 2,937 +/- 744 g in males). Multiple regression analysis shows weight to be a positive sex-independent predictor of serum leptin values (p < 0.0005). Sex also proves to be a predictor of leptin, independently of weight and is higher in females than in males (p < 0.003). CONCLUSION: Leptin is present in placental human cord blood after 30-42 weeks of gestation. Newborn weight and sex are independent predictors of leptin values. SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/10095163/Leptin_values_in_placental_cord_blood_of_human_newborns_with_normal_intrauterine_growth_after_30_42_weeks_of_gestation_ L2 - https://www.karger.com?DOI=10.1159/000023306 DB - PRIME DP - Unbound Medicine ER -