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Accuracy of touch imprint cytology of image-directed breast core needle biopsies.
Acta Cytol. 1999 Mar-Apr; 43(2):169-74.AC

Abstract

OBJECTIVE

To evaluate the accuracy of touch imprint (TI) cytology of image-directed core needle biopsy (CNB) specimens of nonpalpable breast lesions.

STUDY DESIGN

Fifty-two consecutive CNBs from 44 patients were performed under mammographic or ultrasound guidance. Air- dried TIs of CNBs were stained with Diff-Quik. TI cellularity was considered adequate if six or more ductal cell groups were identified. CNBs and TIs were interpreted in a blinded fashion.

RESULTS

TI cellularity was adequate in 37/52 (71%) cases, including 17/20 carcinomas and 20/32 benign lesions. Among 17 carcinomas, TIs were positive in 12, suspicious in 4 and atypical in 1. One case of lactational change was suspicious on TI, and 5/8 fibroadenomas were atypical. No benign lesions were called "carcinoma" on cytology. When lesions categorized as "carcinoma" or "suspicious" were considered positive and those classified as "atypical" or "benign" were scored as negative, TI sensitivity and specificity were 94% and 95%, respectively. When the "atypical" cases were grouped with the positive cases, TI sensitivity was 100%, with 75% specificity.

CONCLUSION

With satisfactory cellularity, TIs of CNBs are highly accurate. When immediate evaluation of CNB specimens is important, TIs can potentially decrease the number of biopsy passes required and provide preliminary diagnoses.

Authors+Show Affiliations

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. tjacobs@bidmc.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10097705

Citation

Jacobs, T W., et al. "Accuracy of Touch Imprint Cytology of Image-directed Breast Core Needle Biopsies." Acta Cytologica, vol. 43, no. 2, 1999, pp. 169-74.
Jacobs TW, Silverman JF, Schroeder B, et al. Accuracy of touch imprint cytology of image-directed breast core needle biopsies. Acta Cytol. 1999;43(2):169-74.
Jacobs, T. W., Silverman, J. F., Schroeder, B., Raza, S., Baum, J. K., & Schnitt, S. J. (1999). Accuracy of touch imprint cytology of image-directed breast core needle biopsies. Acta Cytologica, 43(2), 169-74.
Jacobs TW, et al. Accuracy of Touch Imprint Cytology of Image-directed Breast Core Needle Biopsies. Acta Cytol. 1999 Mar-Apr;43(2):169-74. PubMed PMID: 10097705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accuracy of touch imprint cytology of image-directed breast core needle biopsies. AU - Jacobs,T W, AU - Silverman,J F, AU - Schroeder,B, AU - Raza,S, AU - Baum,J K, AU - Schnitt,S J, PY - 1999/3/31/pubmed PY - 1999/3/31/medline PY - 1999/3/31/entrez SP - 169 EP - 74 JF - Acta cytologica JO - Acta Cytol VL - 43 IS - 2 N2 - OBJECTIVE: To evaluate the accuracy of touch imprint (TI) cytology of image-directed core needle biopsy (CNB) specimens of nonpalpable breast lesions. STUDY DESIGN: Fifty-two consecutive CNBs from 44 patients were performed under mammographic or ultrasound guidance. Air- dried TIs of CNBs were stained with Diff-Quik. TI cellularity was considered adequate if six or more ductal cell groups were identified. CNBs and TIs were interpreted in a blinded fashion. RESULTS: TI cellularity was adequate in 37/52 (71%) cases, including 17/20 carcinomas and 20/32 benign lesions. Among 17 carcinomas, TIs were positive in 12, suspicious in 4 and atypical in 1. One case of lactational change was suspicious on TI, and 5/8 fibroadenomas were atypical. No benign lesions were called "carcinoma" on cytology. When lesions categorized as "carcinoma" or "suspicious" were considered positive and those classified as "atypical" or "benign" were scored as negative, TI sensitivity and specificity were 94% and 95%, respectively. When the "atypical" cases were grouped with the positive cases, TI sensitivity was 100%, with 75% specificity. CONCLUSION: With satisfactory cellularity, TIs of CNBs are highly accurate. When immediate evaluation of CNB specimens is important, TIs can potentially decrease the number of biopsy passes required and provide preliminary diagnoses. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/10097705/Accuracy_of_touch_imprint_cytology_of_image_directed_breast_core_needle_biopsies_ L2 - https://www.karger.com?DOI=10.1159/000330972 DB - PRIME DP - Unbound Medicine ER -