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[Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity].
Gan To Kagaku Ryoho 1999; 26(4):503-8GT

Abstract

In order to prevent the nephrotoxicity induced by cisplatin (CDDP), prostaglandin E1 (PGE1) was administered intravenously after anticancer chemotherapy to six patients with lung cancer. All patients underwent two courses of multi-drug chemotherapy with the same regimen including a single administration of 80 mg/m2 CDDP. From the 7th day of the 2nd course of chemotherapy, 120 micrograms PGE1 had been administered for five days. During the two courses of chemotherapy, serum creatinine, blood urea nitrogen, creatinine clearance (Ccr), 24-h excretions of beta 2-microglobulin (beta 2-MG) and N-acetylglucosaminidase (NAG) in urine were measured every week in all patients. The mean value of Ccr was higher in the 2nd course than in the control course (65 ml/min vs. 74 ml/min). The 24-h excretions of beta 2-MG and NAG were also reduced in the 2nd course. Out of six patients, only one was complicated by mild phlebitis at the PGE1 infusion site. From these results it was suggested that PGE1 was effective for prevention of CDDP nephrotoxicity.

Authors+Show Affiliations

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University.

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

jpn

PubMed ID

10097747

Citation

Takayama, K, et al. "[Preventive Effect of Prostaglandin E1 On Cisplatin-induced Nephrotoxicity]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 26, no. 4, 1999, pp. 503-8.
Takayama K, Nakanishi Y, Takano K, et al. [Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity]. Gan To Kagaku Ryoho. 1999;26(4):503-8.
Takayama, K., Nakanishi, Y., Takano, K., Harada, T., Inoue, K., Osaki, S., ... Hara, N. (1999). [Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 26(4), pp. 503-8.
Takayama K, et al. [Preventive Effect of Prostaglandin E1 On Cisplatin-induced Nephrotoxicity]. Gan To Kagaku Ryoho. 1999;26(4):503-8. PubMed PMID: 10097747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity]. AU - Takayama,K, AU - Nakanishi,Y, AU - Takano,K, AU - Harada,T, AU - Inoue,K, AU - Osaki,S, AU - Minami,T, AU - Hara,N, PY - 1999/3/31/pubmed PY - 1999/3/31/medline PY - 1999/3/31/entrez SP - 503 EP - 8 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 26 IS - 4 N2 - In order to prevent the nephrotoxicity induced by cisplatin (CDDP), prostaglandin E1 (PGE1) was administered intravenously after anticancer chemotherapy to six patients with lung cancer. All patients underwent two courses of multi-drug chemotherapy with the same regimen including a single administration of 80 mg/m2 CDDP. From the 7th day of the 2nd course of chemotherapy, 120 micrograms PGE1 had been administered for five days. During the two courses of chemotherapy, serum creatinine, blood urea nitrogen, creatinine clearance (Ccr), 24-h excretions of beta 2-microglobulin (beta 2-MG) and N-acetylglucosaminidase (NAG) in urine were measured every week in all patients. The mean value of Ccr was higher in the 2nd course than in the control course (65 ml/min vs. 74 ml/min). The 24-h excretions of beta 2-MG and NAG were also reduced in the 2nd course. Out of six patients, only one was complicated by mild phlebitis at the PGE1 infusion site. From these results it was suggested that PGE1 was effective for prevention of CDDP nephrotoxicity. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/10097747/[Preventive_effect_of_prostaglandin_E1_on_cisplatin_induced_nephrotoxicity]_ L2 - https://medlineplus.gov/lungcancer.html DB - PRIME DP - Unbound Medicine ER -