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Regulation of steroid receptor subcellular trafficking.
Cell Biochem Biophys. 1999; 30(1):1-24.CB

Abstract

Cellular responses to external signals often reflect alterations in gene expression. The activation of cell surface hormone or growth factor receptors upon the binding of appropriate ligands mobilizes signal transduction cascades that can ultimately impact the activity of defined sets of transcription factors. The interpretation of hormonal signals can also be initiated intracellularly, as is the case for steroid hormone receptors. In addition to recognizing specific hormones, steroid hormone receptors also function as transcription factors and directly transduce hormonal signals to activation or repression of unique target genes. The delivery of activated steroid receptors to high-affinity genomic sites must be efficient to account for the rapidity and selectivity of many transcriptional responses to steroid hormones. Thus, the signal transduction capacity of steroid hormone receptors will be affected by the efficiency of receptor trafficking both between different subcellular compartments (i.e., the cytoplasm and nucleus) and within a specific compartment (i.e., the nucleus). This article will highlight the recent advances in our understanding of subcellular and subnuclear trafficking of steroid receptors.

Authors+Show Affiliations

Department of Biological Sciences, University of Pittsburgh, PA 15260, USA. dod1@vms.cis.pitt.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10099820

Citation

DeFranco, D B.. "Regulation of Steroid Receptor Subcellular Trafficking." Cell Biochemistry and Biophysics, vol. 30, no. 1, 1999, pp. 1-24.
DeFranco DB. Regulation of steroid receptor subcellular trafficking. Cell Biochem Biophys. 1999;30(1):1-24.
DeFranco, D. B. (1999). Regulation of steroid receptor subcellular trafficking. Cell Biochemistry and Biophysics, 30(1), 1-24.
DeFranco DB. Regulation of Steroid Receptor Subcellular Trafficking. Cell Biochem Biophys. 1999;30(1):1-24. PubMed PMID: 10099820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of steroid receptor subcellular trafficking. A1 - DeFranco,D B, PY - 1999/4/1/pubmed PY - 1999/4/1/medline PY - 1999/4/1/entrez SP - 1 EP - 24 JF - Cell biochemistry and biophysics JO - Cell Biochem Biophys VL - 30 IS - 1 N2 - Cellular responses to external signals often reflect alterations in gene expression. The activation of cell surface hormone or growth factor receptors upon the binding of appropriate ligands mobilizes signal transduction cascades that can ultimately impact the activity of defined sets of transcription factors. The interpretation of hormonal signals can also be initiated intracellularly, as is the case for steroid hormone receptors. In addition to recognizing specific hormones, steroid hormone receptors also function as transcription factors and directly transduce hormonal signals to activation or repression of unique target genes. The delivery of activated steroid receptors to high-affinity genomic sites must be efficient to account for the rapidity and selectivity of many transcriptional responses to steroid hormones. Thus, the signal transduction capacity of steroid hormone receptors will be affected by the efficiency of receptor trafficking both between different subcellular compartments (i.e., the cytoplasm and nucleus) and within a specific compartment (i.e., the nucleus). This article will highlight the recent advances in our understanding of subcellular and subnuclear trafficking of steroid receptors. SN - 1085-9195 UR - https://www.unboundmedicine.com/medline/citation/10099820/Regulation_of_steroid_receptor_subcellular_trafficking_ L2 - https://dx.doi.org/10.1007/BF02737882 DB - PRIME DP - Unbound Medicine ER -