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Body weight and weight gain during adult life in men in relation to coronary heart disease and mortality. A prospective population study.
Eur Heart J. 1999 Feb; 20(4):269-77.EH

Abstract

AIMS

To assess the risk of death from coronary disease, and all causes associated with body mass index and weight gain from age 20 to middle age.

METHODS AND RESULTS

In this study, 6874 men aged 47 to 55 years at baseline and free of a history of myocardial infarction were followed with respect to mortality from coronary disease and from all causes over an average follow-up of 19.7 years, and with respect to non-fatal myocardial infarction for 11.8 years. High body mass index predicted death from coronary disease, but only at levels above 27.5 m.kg-2. Men with stable weight (defined as +/- 4% change from age 20) had the lowest death rate from coronary disease and the lowest risk of non-fatal myocardial infarction. Relative risk of coronary death increased with increasing weight gain, from 1.57 (1.14-2.15) (after adjustment for age, physical activity, and smoking) in the group who gained 4 to 10%, to 2.76 (1.97-3.85) in men with a weight gain of more than 35% (P for trend 0.0001), compared to men who remained stable. After further adjustment for serum cholesterol, systolic blood pressure, and diabetes, relative risks were reduced but still significantly elevated in all weight gain groups (P for trend 0.004). Data concerning non-fatal myocardial infarction were available for the first 11.8 years and showed a relative risk of 3.35 (2.05-5.47) after adjustment for age, physical activity, and smoking in men with a weight gain of more than 35%.

CONCLUSION

Weight gain from age 20, even a very moderate increase, is strongly associated with an increased risk of coronary death and non-fatal myocardial infarction.

Authors+Show Affiliations

Section of Preventive Cardiology, Sahlgrenska University Hospital/Ostra, Göteborg, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10099921

Citation

Rosengren, A, et al. "Body Weight and Weight Gain During Adult Life in Men in Relation to Coronary Heart Disease and Mortality. a Prospective Population Study." European Heart Journal, vol. 20, no. 4, 1999, pp. 269-77.
Rosengren A, Wedel H, Wilhelmsen L. Body weight and weight gain during adult life in men in relation to coronary heart disease and mortality. A prospective population study. Eur Heart J. 1999;20(4):269-77.
Rosengren, A., Wedel, H., & Wilhelmsen, L. (1999). Body weight and weight gain during adult life in men in relation to coronary heart disease and mortality. A prospective population study. European Heart Journal, 20(4), 269-77.
Rosengren A, Wedel H, Wilhelmsen L. Body Weight and Weight Gain During Adult Life in Men in Relation to Coronary Heart Disease and Mortality. a Prospective Population Study. Eur Heart J. 1999;20(4):269-77. PubMed PMID: 10099921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body weight and weight gain during adult life in men in relation to coronary heart disease and mortality. A prospective population study. AU - Rosengren,A, AU - Wedel,H, AU - Wilhelmsen,L, PY - 1999/4/1/pubmed PY - 1999/4/1/medline PY - 1999/4/1/entrez SP - 269 EP - 77 JF - European heart journal JO - Eur Heart J VL - 20 IS - 4 N2 - AIMS: To assess the risk of death from coronary disease, and all causes associated with body mass index and weight gain from age 20 to middle age. METHODS AND RESULTS: In this study, 6874 men aged 47 to 55 years at baseline and free of a history of myocardial infarction were followed with respect to mortality from coronary disease and from all causes over an average follow-up of 19.7 years, and with respect to non-fatal myocardial infarction for 11.8 years. High body mass index predicted death from coronary disease, but only at levels above 27.5 m.kg-2. Men with stable weight (defined as +/- 4% change from age 20) had the lowest death rate from coronary disease and the lowest risk of non-fatal myocardial infarction. Relative risk of coronary death increased with increasing weight gain, from 1.57 (1.14-2.15) (after adjustment for age, physical activity, and smoking) in the group who gained 4 to 10%, to 2.76 (1.97-3.85) in men with a weight gain of more than 35% (P for trend 0.0001), compared to men who remained stable. After further adjustment for serum cholesterol, systolic blood pressure, and diabetes, relative risks were reduced but still significantly elevated in all weight gain groups (P for trend 0.004). Data concerning non-fatal myocardial infarction were available for the first 11.8 years and showed a relative risk of 3.35 (2.05-5.47) after adjustment for age, physical activity, and smoking in men with a weight gain of more than 35%. CONCLUSION: Weight gain from age 20, even a very moderate increase, is strongly associated with an increased risk of coronary death and non-fatal myocardial infarction. SN - 0195-668X UR - https://www.unboundmedicine.com/medline/citation/10099921/Body_weight_and_weight_gain_during_adult_life_in_men_in_relation_to_coronary_heart_disease_and_mortality__A_prospective_population_study_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -