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Wernicke's encephalopathy induced by hyperemesis gravidarum.
Acta Neurol Scand. 1999 Mar; 99(3):196-8.AN

Abstract

A report is presented on a patient with Wernicke's encephalopathy secondary to hyperemesis gravidarum. The 25-year-old female presented 11 weeks into pregnancy with prolonged vomiting. Neurological examination 8 weeks later demonstrated obtunded sensations, nystagmus and ataxia of gait. MR imaging revealed bilateral lesions in the mediodorsal nuclei of thalami, in the hypothalamus and in the periaqueductal gray matter (1). The neurological signs and the MRI findings pointed to a diagnosis of Wernicke's encephalopathy. The patient was treated with intramuscular vitamin B1 followed by oral thiamine until the end of pregnancy. The subsequent course of the pregnancy was uncomplicated, and resulted in the delivery of a healthy 2970 g male infant. A review of the literature published during the last 30 years revealed an additional 20 cases of Wernicke's encephalopathy induced by hyperemesis gravidarum. Only half of these pregnancies resulted in the birth of a normal infant.

Authors+Show Affiliations

Gárdián G
Department of Neurology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Vörös E
No affiliation info available
Járdánházy T
No affiliation info available
Ungureán A
No affiliation info available
Vécsei L
No affiliation info available

MeSH

AdultFemaleHumansHyperemesis GravidarumMagnetic Resonance ImagingPregnancyWernicke Encephalopathy

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10100965

Citation

Gárdián, G, et al. "Wernicke's Encephalopathy Induced By Hyperemesis Gravidarum." Acta Neurologica Scandinavica, vol. 99, no. 3, 1999, pp. 196-8.
Gárdián G, Vörös E, Járdánházy T, et al. Wernicke's encephalopathy induced by hyperemesis gravidarum. Acta Neurol Scand. 1999;99(3):196-8.
Gárdián, G., Vörös, E., Járdánházy, T., Ungureán, A., & Vécsei, L. (1999). Wernicke's encephalopathy induced by hyperemesis gravidarum. Acta Neurologica Scandinavica, 99(3), 196-8.
Gárdián G, et al. Wernicke's Encephalopathy Induced By Hyperemesis Gravidarum. Acta Neurol Scand. 1999;99(3):196-8. PubMed PMID: 10100965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wernicke's encephalopathy induced by hyperemesis gravidarum. AU - Gárdián,G, AU - Vörös,E, AU - Járdánházy,T, AU - Ungureán,A, AU - Vécsei,L, PY - 1999/4/1/pubmed PY - 1999/4/1/medline PY - 1999/4/1/entrez SP - 196 EP - 8 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 99 IS - 3 N2 - A report is presented on a patient with Wernicke's encephalopathy secondary to hyperemesis gravidarum. The 25-year-old female presented 11 weeks into pregnancy with prolonged vomiting. Neurological examination 8 weeks later demonstrated obtunded sensations, nystagmus and ataxia of gait. MR imaging revealed bilateral lesions in the mediodorsal nuclei of thalami, in the hypothalamus and in the periaqueductal gray matter (1). The neurological signs and the MRI findings pointed to a diagnosis of Wernicke's encephalopathy. The patient was treated with intramuscular vitamin B1 followed by oral thiamine until the end of pregnancy. The subsequent course of the pregnancy was uncomplicated, and resulted in the delivery of a healthy 2970 g male infant. A review of the literature published during the last 30 years revealed an additional 20 cases of Wernicke's encephalopathy induced by hyperemesis gravidarum. Only half of these pregnancies resulted in the birth of a normal infant. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/10100965/Wernicke's_encephalopathy_induced_by_hyperemesis_gravidarum_ DB - PRIME DP - Unbound Medicine ER -