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Free radicals in disease.
Semin Reprod Endocrinol 1998; 16(4):241-8SR

Abstract

Partial reduction of molecular oxygen can generate reactive oxygen species (ROS), including the hydrogen peroxide, and the free radicals superoxide and hydroxyl. The formation of ROS is a feature of many degenerative diseases, such as atherosclerosis and neurodegeneration, Organisms contain a battery of defense mechanisms to prevent the formation of ROS, to scavenge them, and to repair the damage they cause. Free radicals are also involved in signal transduction pathways. For example, the free radical nitric oxide is involved in signal transduction in both the cardiovascular and central nervous systems. The interplay between nitric oxide and ROS has been a major focus of recent studies, as nitric oxide is an efficient radical scavenger. However, in some cases, such as in the formation of peroxynitrite from nitric oxide and superoxide, the product is potentially more deleterious that the parent radicals. This review describes the major chemical species involved in oxidative stress and free radical biochemistry, and gives a brief overview of their role in pathological conditions.

Authors+Show Affiliations

Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10101806

Citation

Hogg, N. "Free Radicals in Disease." Seminars in Reproductive Endocrinology, vol. 16, no. 4, 1998, pp. 241-8.
Hogg N. Free radicals in disease. Semin Reprod Endocrinol. 1998;16(4):241-8.
Hogg, N. (1998). Free radicals in disease. Seminars in Reproductive Endocrinology, 16(4), pp. 241-8.
Hogg N. Free Radicals in Disease. Semin Reprod Endocrinol. 1998;16(4):241-8. PubMed PMID: 10101806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Free radicals in disease. A1 - Hogg,N, PY - 1999/4/2/pubmed PY - 1999/4/2/medline PY - 1999/4/2/entrez SP - 241 EP - 8 JF - Seminars in reproductive endocrinology JO - Semin. Reprod. Endocrinol. VL - 16 IS - 4 N2 - Partial reduction of molecular oxygen can generate reactive oxygen species (ROS), including the hydrogen peroxide, and the free radicals superoxide and hydroxyl. The formation of ROS is a feature of many degenerative diseases, such as atherosclerosis and neurodegeneration, Organisms contain a battery of defense mechanisms to prevent the formation of ROS, to scavenge them, and to repair the damage they cause. Free radicals are also involved in signal transduction pathways. For example, the free radical nitric oxide is involved in signal transduction in both the cardiovascular and central nervous systems. The interplay between nitric oxide and ROS has been a major focus of recent studies, as nitric oxide is an efficient radical scavenger. However, in some cases, such as in the formation of peroxynitrite from nitric oxide and superoxide, the product is potentially more deleterious that the parent radicals. This review describes the major chemical species involved in oxidative stress and free radical biochemistry, and gives a brief overview of their role in pathological conditions. SN - 0734-8630 UR - https://www.unboundmedicine.com/medline/citation/10101806/Free_radicals_in_disease_ DB - PRIME DP - Unbound Medicine ER -