Lebrun, A, and R Lavery. "Modeling DNA Deformations Induced By Minor Groove Binding Proteins." Biopolymers, vol. 49, no. 5, 1999, pp. 341-53.
Lebrun A, Lavery R. Modeling DNA deformations induced by minor groove binding proteins. Biopolymers. 1999;49(5):341-53.
Lebrun, A., & Lavery, R. (1999). Modeling DNA deformations induced by minor groove binding proteins. Biopolymers, 49(5), 341-53.
Lebrun A, Lavery R. Modeling DNA Deformations Induced By Minor Groove Binding Proteins. Biopolymers. 1999 Apr 15;49(5):341-53. PubMed PMID: 10101970.
TY - JOUR
T1 - Modeling DNA deformations induced by minor groove binding proteins.
AU - Lebrun,A,
AU - Lavery,R,
PY - 1999/4/2/pubmed
PY - 2000/6/20/medline
PY - 1999/4/2/entrez
SP - 341
EP - 53
JF - Biopolymers
JO - Biopolymers
VL - 49
IS - 5
N2 - Molecular modeling is used to demonstrate that the major structural deformations of DNA caused by four different minor groove binding proteins, TBP, SRY, LEF-1, and PurR, can all be mimicked by stretching the double helix between two 3'-phosphate groups flanking the binding region. This deformation reproduces the widening of the minor groove and the overall bending and unwinding of DNA caused by protein binding. It also reproduces the principal kinks associated with partially intercalated amino acid side chains, observed with such interactions. In addition, when protein binding involves a local transition to an A-like conformation, phosphate neutralization, via the formation of protein-DNA salt bridges, appears to favor the resulting deformation.
SN - 0006-3525
UR - https://www.unboundmedicine.com/medline/citation/10101970/Modeling_DNA_deformations_induced_by_minor_groove_binding_proteins_
L2 - https://doi.org/10.1002/(SICI)1097-0282(19990415)49:5<341::AID-BIP1>3.0.CO;2-C
DB - PRIME
DP - Unbound Medicine