Tags

Type your tag names separated by a space and hit enter

Asymmetry in optic disc parameters: the Blue Mountains Eye Study.
Invest Ophthalmol Vis Sci 1999; 40(5):849-57IO

Abstract

PURPOSE

To examine asymmetry in vertical optic disc parameters among subjects classified as normal, as having ocular hypertension (OH), and as having open-angle glaucoma (OAG) in a population-based sample.

METHODS

The Blue Mountains Eye Study examined 3654 people aged 49 to 97 years, including 2929 normal subjects, 118 with OH, and 79 with OAG in the groups of interest for the asymmetry study. Optic disc parameters were measured in a masked manner from stereo optic disc photographs.

RESULTS

Vertical disc diameter asymmetry (the absolute value of left minus right disc diameters) was similar among normal, OH, and OAG groups (median, 0.07-0.08 mm). Vertical cup- disc ratio asymmetry was higher in patients with OAG (median, 0.11) than in normal subjects (median, 0.06; P < 0.0001) and in those with OH (median, 0.05; P < 0.0001) but was similar between normal subjects and patients with OH (P = 0.17). A cup- disc ratio asymmetry of 0.2 or more was found in 24% of patients with OAG, compared with 1% of patients with OH and 6% of normal subjects. Corresponding rates for cup- disc ratio asymmetry of 0.3 or more in these three groups were 10%, 0%, and 1%, respectively. Using multiple linear regression, cup-disc ratio asymmetry was associated with disc diameter asymmetry and intraocular pressure asymmetry. However, these two factors explained only 3% of the variability of cup- disc ratio asymmetry and 20% of cup diameter asymmetry.

CONCLUSIONS

Despite differences between the OAG group and either the OH or normal groups, asymmetry alone was not useful in identifying patients with OAG. At all levels of asymmetry, subjects were more likely to be classified as normal than with OH or OAG.

Authors+Show Affiliations

Department of Ophthalmology, the University of Sydney, Westmead Hospital, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10102281

Citation

Ong, L S., et al. "Asymmetry in Optic Disc Parameters: the Blue Mountains Eye Study." Investigative Ophthalmology & Visual Science, vol. 40, no. 5, 1999, pp. 849-57.
Ong LS, Mitchell P, Healey PR, et al. Asymmetry in optic disc parameters: the Blue Mountains Eye Study. Invest Ophthalmol Vis Sci. 1999;40(5):849-57.
Ong, L. S., Mitchell, P., Healey, P. R., & Cumming, R. G. (1999). Asymmetry in optic disc parameters: the Blue Mountains Eye Study. Investigative Ophthalmology & Visual Science, 40(5), pp. 849-57.
Ong LS, et al. Asymmetry in Optic Disc Parameters: the Blue Mountains Eye Study. Invest Ophthalmol Vis Sci. 1999;40(5):849-57. PubMed PMID: 10102281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymmetry in optic disc parameters: the Blue Mountains Eye Study. AU - Ong,L S, AU - Mitchell,P, AU - Healey,P R, AU - Cumming,R G, PY - 1999/4/2/pubmed PY - 1999/4/2/medline PY - 1999/4/2/entrez SP - 849 EP - 57 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 40 IS - 5 N2 - PURPOSE: To examine asymmetry in vertical optic disc parameters among subjects classified as normal, as having ocular hypertension (OH), and as having open-angle glaucoma (OAG) in a population-based sample. METHODS: The Blue Mountains Eye Study examined 3654 people aged 49 to 97 years, including 2929 normal subjects, 118 with OH, and 79 with OAG in the groups of interest for the asymmetry study. Optic disc parameters were measured in a masked manner from stereo optic disc photographs. RESULTS: Vertical disc diameter asymmetry (the absolute value of left minus right disc diameters) was similar among normal, OH, and OAG groups (median, 0.07-0.08 mm). Vertical cup- disc ratio asymmetry was higher in patients with OAG (median, 0.11) than in normal subjects (median, 0.06; P < 0.0001) and in those with OH (median, 0.05; P < 0.0001) but was similar between normal subjects and patients with OH (P = 0.17). A cup- disc ratio asymmetry of 0.2 or more was found in 24% of patients with OAG, compared with 1% of patients with OH and 6% of normal subjects. Corresponding rates for cup- disc ratio asymmetry of 0.3 or more in these three groups were 10%, 0%, and 1%, respectively. Using multiple linear regression, cup-disc ratio asymmetry was associated with disc diameter asymmetry and intraocular pressure asymmetry. However, these two factors explained only 3% of the variability of cup- disc ratio asymmetry and 20% of cup diameter asymmetry. CONCLUSIONS: Despite differences between the OAG group and either the OH or normal groups, asymmetry alone was not useful in identifying patients with OAG. At all levels of asymmetry, subjects were more likely to be classified as normal than with OH or OAG. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/10102281/Asymmetry_in_optic_disc_parameters:_the_Blue_Mountains_Eye_Study_ L2 - http://iovs.arvojournals.org/article.aspx?volume=40&amp;page=849 DB - PRIME DP - Unbound Medicine ER -