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Eradication of Helicobacter pylori infection after ranitidine bismuth citrate, metronidazole and tetracycline for 7 or 10 days.
Aliment Pharmacol Ther 1999; 13(3):323-6AP

Abstract

BACKGROUND

We assessed the efficacy, tolerance, and compliance of twice-daily triple therapy for Helicobacter pylori with ranitidine bismuth citrate, metronidazole and tetracycline for 7 or 10 days.

METHODS

105 subjects with H. pylori infection documented by the 13C-urea breath test were randomly assigned to a 7 or 10-day course of ranitidine bismuth citrate 400 mg b.d., metronidazole 500 mg b.d. and tetracycline 500 mg b.d. Subjects returned at the end of therapy for assessment of side-effects and pill count. A repeat 13C-urea breath test was obtained 4 or more weeks after completion of therapy and cure of infection was defined as a negative test result.

RESULTS

Poor compliance (< 80% of medications) was seen in 2% of subjects randomized to 7 days of therapy and in 10% randomized to 10 days of therapy (P = N.S.). Intention-to-treat eradication rates were 56% for 7-day and 60% for 10-day therapy (P = N.S.). Per protocol eradication rates were 58% for 7-day and 61% for 10-day therapy (P = N.S.). The 10-day intention-to-treat eradication rate for males was 78% and 32% for females (P < 0.01) and per protocol eradication rates were 79% and 31%, respectively (P < 0.01).

CONCLUSIONS

Despite excellent compliance and tolerance, neither 7 nor 10 days of therapy with twice-daily ranitidine bismuth citrate, metronidazole and tetracycline are adequate as a treatment of H. pylori infection.

Authors+Show Affiliations

Veterans Affairs Medical Center and Oregon Health Sciences University, Portland, Oregon, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10102965

Citation

Knigge, K, et al. "Eradication of Helicobacter Pylori Infection After Ranitidine Bismuth Citrate, Metronidazole and Tetracycline for 7 or 10 Days." Alimentary Pharmacology & Therapeutics, vol. 13, no. 3, 1999, pp. 323-6.
Knigge K, Kelly C, Peterson WL, et al. Eradication of Helicobacter pylori infection after ranitidine bismuth citrate, metronidazole and tetracycline for 7 or 10 days. Aliment Pharmacol Ther. 1999;13(3):323-6.
Knigge, K., Kelly, C., Peterson, W. L., & Fennerty, M. B. (1999). Eradication of Helicobacter pylori infection after ranitidine bismuth citrate, metronidazole and tetracycline for 7 or 10 days. Alimentary Pharmacology & Therapeutics, 13(3), pp. 323-6.
Knigge K, et al. Eradication of Helicobacter Pylori Infection After Ranitidine Bismuth Citrate, Metronidazole and Tetracycline for 7 or 10 Days. Aliment Pharmacol Ther. 1999;13(3):323-6. PubMed PMID: 10102965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eradication of Helicobacter pylori infection after ranitidine bismuth citrate, metronidazole and tetracycline for 7 or 10 days. AU - Knigge,K, AU - Kelly,C, AU - Peterson,W L, AU - Fennerty,M B, PY - 1999/4/2/pubmed PY - 1999/4/2/medline PY - 1999/4/2/entrez SP - 323 EP - 6 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 13 IS - 3 N2 - BACKGROUND: We assessed the efficacy, tolerance, and compliance of twice-daily triple therapy for Helicobacter pylori with ranitidine bismuth citrate, metronidazole and tetracycline for 7 or 10 days. METHODS: 105 subjects with H. pylori infection documented by the 13C-urea breath test were randomly assigned to a 7 or 10-day course of ranitidine bismuth citrate 400 mg b.d., metronidazole 500 mg b.d. and tetracycline 500 mg b.d. Subjects returned at the end of therapy for assessment of side-effects and pill count. A repeat 13C-urea breath test was obtained 4 or more weeks after completion of therapy and cure of infection was defined as a negative test result. RESULTS: Poor compliance (< 80% of medications) was seen in 2% of subjects randomized to 7 days of therapy and in 10% randomized to 10 days of therapy (P = N.S.). Intention-to-treat eradication rates were 56% for 7-day and 60% for 10-day therapy (P = N.S.). Per protocol eradication rates were 58% for 7-day and 61% for 10-day therapy (P = N.S.). The 10-day intention-to-treat eradication rate for males was 78% and 32% for females (P < 0.01) and per protocol eradication rates were 79% and 31%, respectively (P < 0.01). CONCLUSIONS: Despite excellent compliance and tolerance, neither 7 nor 10 days of therapy with twice-daily ranitidine bismuth citrate, metronidazole and tetracycline are adequate as a treatment of H. pylori infection. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/10102965/Eradication_of_Helicobacter_pylori_infection_after_ranitidine_bismuth_citrate_metronidazole_and_tetracycline_for_7_or_10_days_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=1999&amp;volume=13&amp;issue=3&amp;spage=323 DB - PRIME DP - Unbound Medicine ER -