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Reverse triiodothyronine, thyroid hormone, and thyrotrophin concentrations in placental cord blood.
Arch Dis Child. 1978 Aug; 53(8):620-4.AD

Abstract

Reverse triiodothyronine (rT3), triiodothyronine (T3), thyroxine (T4), thyroxine binding globulin (TBG), and thyrotrophin (TSH) were measured in sera from placental cord blood in an unselected series of 272 deliveries. In this series the concentrations of rT3 (mean 3.33 nmol/l, 95% confidence limits 1.6--7.0 nmol/l), were log normally distributed and did not overlap the adult normal range (0.11--0.44 nmol/l). There were no correlations between the cord blood concentrations of rT3, T3, T4, and TSH. The cord serum rT3 concentration was not influenced by maturity, birth-weight, or neonatal risk factors, whereas these factors did affect the concentrations of T3, T4, AND TBG. There is no arteriovenous rT3 concentration difference across the placenta, therefore the cord rT3 reflects the systemic rT3 concentration in the baby at birth. As rT3 in the neonate largely, if not entirely, derives from thyroxine from the fetal thyroid, measurement of the cord rT3 concentration may be a good immediate screening test for neonatal hypothyroidism.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

101154

Citation

Byfield, P G., et al. "Reverse Triiodothyronine, Thyroid Hormone, and Thyrotrophin Concentrations in Placental Cord Blood." Archives of Disease in Childhood, vol. 53, no. 8, 1978, pp. 620-4.
Byfield PG, Bird D, Yepez R, et al. Reverse triiodothyronine, thyroid hormone, and thyrotrophin concentrations in placental cord blood. Arch Dis Child. 1978;53(8):620-4.
Byfield, P. G., Bird, D., Yepez, R., Land, M., & Himsworth, R. L. (1978). Reverse triiodothyronine, thyroid hormone, and thyrotrophin concentrations in placental cord blood. Archives of Disease in Childhood, 53(8), 620-4.
Byfield PG, et al. Reverse Triiodothyronine, Thyroid Hormone, and Thyrotrophin Concentrations in Placental Cord Blood. Arch Dis Child. 1978;53(8):620-4. PubMed PMID: 101154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reverse triiodothyronine, thyroid hormone, and thyrotrophin concentrations in placental cord blood. AU - Byfield,P G, AU - Bird,D, AU - Yepez,R, AU - Land,M, AU - Himsworth,R L, PY - 1978/8/1/pubmed PY - 1978/8/1/medline PY - 1978/8/1/entrez SP - 620 EP - 4 JF - Archives of disease in childhood JO - Arch. Dis. Child. VL - 53 IS - 8 N2 - Reverse triiodothyronine (rT3), triiodothyronine (T3), thyroxine (T4), thyroxine binding globulin (TBG), and thyrotrophin (TSH) were measured in sera from placental cord blood in an unselected series of 272 deliveries. In this series the concentrations of rT3 (mean 3.33 nmol/l, 95% confidence limits 1.6--7.0 nmol/l), were log normally distributed and did not overlap the adult normal range (0.11--0.44 nmol/l). There were no correlations between the cord blood concentrations of rT3, T3, T4, and TSH. The cord serum rT3 concentration was not influenced by maturity, birth-weight, or neonatal risk factors, whereas these factors did affect the concentrations of T3, T4, AND TBG. There is no arteriovenous rT3 concentration difference across the placenta, therefore the cord rT3 reflects the systemic rT3 concentration in the baby at birth. As rT3 in the neonate largely, if not entirely, derives from thyroxine from the fetal thyroid, measurement of the cord rT3 concentration may be a good immediate screening test for neonatal hypothyroidism. SN - 1468-2044 UR - https://www.unboundmedicine.com/medline/citation/101154/Reverse_triiodothyronine_thyroid_hormone_and_thyrotrophin_concentrations_in_placental_cord_blood_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/101154/ DB - PRIME DP - Unbound Medicine ER -