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Phytochemical characterization of various St. John's Wort extracts.
Adv Ther 1998 Mar-Apr; 15(2):117-28AT

Abstract

Hypericum perforatum is used for its beneficial effects on the nervous system, especially as an antidepressant. Owing to the fast-growing St. John's Wort market in the United States, more and more products (herb and extract) are sold at different quality levels. The amount of well-dried H. perforatum plant material is limited and other species with differing composition and no proof of efficacy are sold. The generally used method for standardization--spectrophotometric determination of naphthodianthrones--is not as selective as a high-performance liquid chromatographic (HPLC) method and can be manipulated (eg, by adding colorants). The different analytical methods used for characterization of St. John's Wort are discussed and a combined spectrophotometric and HPLC method is proposed. Qualitative and quantitative ranges for pharmaceutically relevant compounds of St. John's Wort extracts are cited and the composition of European, US, and Far East extracts is detailed. The influence of the production process, which involves extraction solvents, on phytochemical composition is also described.

Authors+Show Affiliations

H. Finzelberg's Nachf. GmbH & Co KG, Andernach, Germany.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10180998

Citation

Kurth, H, and R Spreemann. "Phytochemical Characterization of Various St. John's Wort Extracts." Advances in Therapy, vol. 15, no. 2, 1998, pp. 117-28.
Kurth H, Spreemann R. Phytochemical characterization of various St. John's Wort extracts. Adv Ther. 1998;15(2):117-28.
Kurth, H., & Spreemann, R. (1998). Phytochemical characterization of various St. John's Wort extracts. Advances in Therapy, 15(2), pp. 117-28.
Kurth H, Spreemann R. Phytochemical Characterization of Various St. John's Wort Extracts. Adv Ther. 1998;15(2):117-28. PubMed PMID: 10180998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemical characterization of various St. John's Wort extracts. AU - Kurth,H, AU - Spreemann,R, PY - 1998/2/6/pubmed PY - 1998/2/6/medline PY - 1998/2/6/entrez SP - 117 EP - 28 JF - Advances in therapy JO - Adv Ther VL - 15 IS - 2 N2 - Hypericum perforatum is used for its beneficial effects on the nervous system, especially as an antidepressant. Owing to the fast-growing St. John's Wort market in the United States, more and more products (herb and extract) are sold at different quality levels. The amount of well-dried H. perforatum plant material is limited and other species with differing composition and no proof of efficacy are sold. The generally used method for standardization--spectrophotometric determination of naphthodianthrones--is not as selective as a high-performance liquid chromatographic (HPLC) method and can be manipulated (eg, by adding colorants). The different analytical methods used for characterization of St. John's Wort are discussed and a combined spectrophotometric and HPLC method is proposed. Qualitative and quantitative ranges for pharmaceutically relevant compounds of St. John's Wort extracts are cited and the composition of European, US, and Far East extracts is detailed. The influence of the production process, which involves extraction solvents, on phytochemical composition is also described. SN - 0741-238X UR - https://www.unboundmedicine.com/medline/citation/10180998/Phytochemical_characterization_of_various_St__John's_Wort_extracts_ L2 - https://medlineplus.gov/antidepressants.html DB - PRIME DP - Unbound Medicine ER -