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Antibody to parietal cells in patients with duodenal ulcer, and relationship to pernicious anaemia.
Med J Aust. 1976 Dec 11; 2(24):900-2.MJ

Abstract

Of 160 patients with pernicious anaemia, none had current duodenal ulceration, whereas in a random population of similar age and sex distribution some 5% would be expected to have a duodenal ulcer. Parietal-cell antibody was detected in serum from 8 of 169 men (4-7%) and from 2 to 31 women (6-4%) with duodenal ulceration. None of the 200 duodenal ulcer patients had antibody to intrinsic factor. The prevalence of these antibodies in duodenal ulcer patients was not significantly different from that in control subjects of similar age and sex distribution. The decreased prevalance of duodenal ulcer in pernicious anaemia patients implies that pernicious anaemia must be less prevalent in duodenal ulcer patients than in a random population; but it appears that this cannot be attributed to an absence of gastric autoimmunity in patients with duodenal ulcer. To resolve this disrepancy, we suggest that pernicious anaemia is determined not only by autoimmune reactions, but also by independent genetic and environmental factors which influence the state of the gastric mucosa.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1018665

Citation

Ungar, B, et al. "Antibody to Parietal Cells in Patients With Duodenal Ulcer, and Relationship to Pernicious Anaemia." The Medical Journal of Australia, vol. 2, no. 24, 1976, pp. 900-2.
Ungar B, Francis CM, Cowling DC. Antibody to parietal cells in patients with duodenal ulcer, and relationship to pernicious anaemia. Med J Aust. 1976;2(24):900-2.
Ungar, B., Francis, C. M., & Cowling, D. C. (1976). Antibody to parietal cells in patients with duodenal ulcer, and relationship to pernicious anaemia. The Medical Journal of Australia, 2(24), 900-2.
Ungar B, Francis CM, Cowling DC. Antibody to Parietal Cells in Patients With Duodenal Ulcer, and Relationship to Pernicious Anaemia. Med J Aust. 1976 Dec 11;2(24):900-2. PubMed PMID: 1018665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibody to parietal cells in patients with duodenal ulcer, and relationship to pernicious anaemia. AU - Ungar,B, AU - Francis,C M, AU - Cowling,D C, PY - 1976/12/11/pubmed PY - 1976/12/11/medline PY - 1976/12/11/entrez SP - 900 EP - 2 JF - The Medical journal of Australia JO - Med J Aust VL - 2 IS - 24 N2 - Of 160 patients with pernicious anaemia, none had current duodenal ulceration, whereas in a random population of similar age and sex distribution some 5% would be expected to have a duodenal ulcer. Parietal-cell antibody was detected in serum from 8 of 169 men (4-7%) and from 2 to 31 women (6-4%) with duodenal ulceration. None of the 200 duodenal ulcer patients had antibody to intrinsic factor. The prevalence of these antibodies in duodenal ulcer patients was not significantly different from that in control subjects of similar age and sex distribution. The decreased prevalance of duodenal ulcer in pernicious anaemia patients implies that pernicious anaemia must be less prevalent in duodenal ulcer patients than in a random population; but it appears that this cannot be attributed to an absence of gastric autoimmunity in patients with duodenal ulcer. To resolve this disrepancy, we suggest that pernicious anaemia is determined not only by autoimmune reactions, but also by independent genetic and environmental factors which influence the state of the gastric mucosa. SN - 0025-729X UR - https://www.unboundmedicine.com/medline/citation/1018665/Antibody_to_parietal_cells_in_patients_with_duodenal_ulcer_and_relationship_to_pernicious_anaemia_ DB - PRIME DP - Unbound Medicine ER -