Tags

Type your tag names separated by a space and hit enter

Topical application of yeast extract accelerates the wound healing of diabetic mice.

Abstract

Alcoholic extracts of yeast have been used as the active ingredient in medications under names such as "tissue or skin respiratory factor," Biodyne (Sperti Drug Co, Cincinnati, Ohio--now defunct), and live yeast cell derivative (LYCD). Beneficial clinical results from the use of LYCD have been reported for the treatment of burns, wounds, and hemorrhoids. The medicinal effects of LYCD have recently been localized to a protein fraction containing a mixture of several peptides. The effects of topical application of the peptide mixture on wounds were examined in diabetic mice, an animal model in which the healing process is disrupted and delayed. Full-thickness wounds were created on the backs of diabetic (DB) and nondiabetic (non-DB) mice. Half of the DB and non-DB mice were treated with 0.05 mL of LYCD after wounding and for 4 successive days. All other mice received vehicle. Wound areas were measured at Day 0 and at 2-day intervals. Mice were sacrificed at 3, 7, 10, 21, and 28 days postinjury. Differences in the extent and quality of healing appeared between DB mice receiving LYCD and DB mice receiving vehicle by day 10 (P < .0001). By 24 days postinjury, DB mice receiving LYCD had achieved 100% wound closure, whereas DB mice receiving vehicle had achieved only 31.4% wound closure. Histologic examination of wounds reflected improved wound healing in DB mice receiving LYCD as compared with those receiving vehicle. A topically applied yeast extract peptide mixture significantly attenuates wound closure and the degree of cellular reorganization of full-thickness excisional wounds of DB mice.

Links

  • Aggregator Full Text
  • Authors+Show Affiliations

    ,

    Shriners Hospitals for Children-Cincinnati Burns Institute, Research Department, OH 45229-3095, USA.

    , , ,

    Source

    MeSH

    Administration, Topical
    Analysis of Variance
    Animals
    Biological Dressings
    Biological Products
    Burns
    Disease Models, Animal
    Female
    Mice
    Mice, Inbred C57BL
    Mice, Inbred NOD
    Peptides
    Statistics, Nonparametric
    Wound Healing

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    10188114

    Citation

    Crowe, M J., et al. "Topical Application of Yeast Extract Accelerates the Wound Healing of Diabetic Mice." The Journal of Burn Care & Rehabilitation, vol. 20, no. 2, 1999, pp. 155-62.
    Crowe MJ, McNeill RB, Schlemm DJ, et al. Topical application of yeast extract accelerates the wound healing of diabetic mice. J Burn Care Rehabil. 1999;20(2):155-62.
    Crowe, M. J., McNeill, R. B., Schlemm, D. J., Greenhalgh, D. G., & Keller, S. J. (1999). Topical application of yeast extract accelerates the wound healing of diabetic mice. The Journal of Burn Care & Rehabilitation, 20(2), pp. 155-62.
    Crowe MJ, et al. Topical Application of Yeast Extract Accelerates the Wound Healing of Diabetic Mice. J Burn Care Rehabil. 1999;20(2):155-62. PubMed PMID: 10188114.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Topical application of yeast extract accelerates the wound healing of diabetic mice. AU - Crowe,M J, AU - McNeill,R B, AU - Schlemm,D J, AU - Greenhalgh,D G, AU - Keller,S J, PY - 1999/4/3/pubmed PY - 1999/4/3/medline PY - 1999/4/3/entrez SP - 155 EP - 62 JF - The Journal of burn care & rehabilitation JO - J Burn Care Rehabil VL - 20 IS - 2 N2 - Alcoholic extracts of yeast have been used as the active ingredient in medications under names such as "tissue or skin respiratory factor," Biodyne (Sperti Drug Co, Cincinnati, Ohio--now defunct), and live yeast cell derivative (LYCD). Beneficial clinical results from the use of LYCD have been reported for the treatment of burns, wounds, and hemorrhoids. The medicinal effects of LYCD have recently been localized to a protein fraction containing a mixture of several peptides. The effects of topical application of the peptide mixture on wounds were examined in diabetic mice, an animal model in which the healing process is disrupted and delayed. Full-thickness wounds were created on the backs of diabetic (DB) and nondiabetic (non-DB) mice. Half of the DB and non-DB mice were treated with 0.05 mL of LYCD after wounding and for 4 successive days. All other mice received vehicle. Wound areas were measured at Day 0 and at 2-day intervals. Mice were sacrificed at 3, 7, 10, 21, and 28 days postinjury. Differences in the extent and quality of healing appeared between DB mice receiving LYCD and DB mice receiving vehicle by day 10 (P < .0001). By 24 days postinjury, DB mice receiving LYCD had achieved 100% wound closure, whereas DB mice receiving vehicle had achieved only 31.4% wound closure. Histologic examination of wounds reflected improved wound healing in DB mice receiving LYCD as compared with those receiving vehicle. A topically applied yeast extract peptide mixture significantly attenuates wound closure and the degree of cellular reorganization of full-thickness excisional wounds of DB mice. SN - 0273-8481 UR - https://www.unboundmedicine.com/medline/citation/10188114/Topical_application_of_yeast_extract_accelerates_the_wound_healing_of_diabetic_mice_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=10188114.ui DB - PRIME DP - Unbound Medicine ER -