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Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden)
Cancer Causes Control 1998; 9(6):559-66CC

Abstract

OBJECTIVES

Dairy products consistently have been associated with an increased risk of prostate cancer, yet the mechanism of this relationship remains unknown. Recent hypotheses propose that 1,25 dihydroxyvitamin D (1,25 D) is protective for prostate cancer. One study in the United States found that calcium consumption, which can lower circulating 1,25 D, was associated with higher risk of advanced prostate cancer, and we sought to address this hypothesis in a distinct population.

METHODS

We analyzed data from a population-based case-control study of prostate cancer conducted in Orebro, Sweden, with 526 cases and 536 controls. Using unconditional logistic regression models, we examined the relationship of dairy products, dietary calcium, phosphorous, and vitamin D with risk of total, extraprostatic, and metastatic prostate cancer.

RESULTS

Calcium intake was an independent predictor of prostate cancer (relative risk (RR) = 1.91, 95 percent confidence interval (CI) 1.23-2.97 for intake > or = 1183 vs. < 825 mg/day), especially for metastatic tumors (RR = 2.64, 95 percent CI 1.24-5.61), controlling for age, family history of prostate cancer, smoking, and total energy and phosphorous intakes. High consumption of dairy products was associated with a 50 percent increased risk of prostate cancer.

CONCLUSIONS

Our results support the hypothesis that high calcium intake may increase risk of prostate cancer, and this relation may underlie previously observed associations between dairy products and prostate cancer.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10189041

Citation

Chan, J M., et al. "Dairy Products, Calcium, Phosphorous, Vitamin D, and Risk of Prostate Cancer (Sweden)." Cancer Causes & Control : CCC, vol. 9, no. 6, 1998, pp. 559-66.
Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden). Cancer Causes Control. 1998;9(6):559-66.
Chan, J. M., Giovannucci, E., Andersson, S. O., Yuen, J., Adami, H. O., & Wolk, A. (1998). Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden). Cancer Causes & Control : CCC, 9(6), pp. 559-66.
Chan JM, et al. Dairy Products, Calcium, Phosphorous, Vitamin D, and Risk of Prostate Cancer (Sweden). Cancer Causes Control. 1998;9(6):559-66. PubMed PMID: 10189041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden) AU - Chan,J M, AU - Giovannucci,E, AU - Andersson,S O, AU - Yuen,J, AU - Adami,H O, AU - Wolk,A, PY - 1999/4/3/pubmed PY - 1999/4/3/medline PY - 1999/4/3/entrez SP - 559 EP - 66 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 9 IS - 6 N2 - OBJECTIVES: Dairy products consistently have been associated with an increased risk of prostate cancer, yet the mechanism of this relationship remains unknown. Recent hypotheses propose that 1,25 dihydroxyvitamin D (1,25 D) is protective for prostate cancer. One study in the United States found that calcium consumption, which can lower circulating 1,25 D, was associated with higher risk of advanced prostate cancer, and we sought to address this hypothesis in a distinct population. METHODS: We analyzed data from a population-based case-control study of prostate cancer conducted in Orebro, Sweden, with 526 cases and 536 controls. Using unconditional logistic regression models, we examined the relationship of dairy products, dietary calcium, phosphorous, and vitamin D with risk of total, extraprostatic, and metastatic prostate cancer. RESULTS: Calcium intake was an independent predictor of prostate cancer (relative risk (RR) = 1.91, 95 percent confidence interval (CI) 1.23-2.97 for intake > or = 1183 vs. < 825 mg/day), especially for metastatic tumors (RR = 2.64, 95 percent CI 1.24-5.61), controlling for age, family history of prostate cancer, smoking, and total energy and phosphorous intakes. High consumption of dairy products was associated with a 50 percent increased risk of prostate cancer. CONCLUSIONS: Our results support the hypothesis that high calcium intake may increase risk of prostate cancer, and this relation may underlie previously observed associations between dairy products and prostate cancer. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/10189041/Dairy_products_calcium_phosphorous_vitamin_D_and_risk_of_prostate_cancer__Sweden_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=10189041.ui DB - PRIME DP - Unbound Medicine ER -