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[Post-exposure HIV prevention: eligibility of patients recently infected by sexual exposure].
Schweiz Med Wochenschr. 1999 Feb 27; 129(8):314-8.SM

Abstract

QUESTION

Post-exposure prophylaxis (PEP) is effective in preventing HIV infection after professional exposure. PEP is also recommended after inadvertent sexual exposure if two conditions are met: the source person is known to be HIV infected, and exposure to this person occurred only once or is accidental. The objective of this study is to describe the circumstances of sexual exposure and determine how frequently these conditions were present among patients diagnosed during primary HIV infection.

METHODS

Physicians of 35 patients diagnosed with primary HIV infection provided detailed information on the circumstances of infection as well as on the patients and source persons.

RESULTS

Most patients were homosexual (71%), and 91% were male. Only one patient (3%) had a single exposure with a known HIV-infected person and was therefore eligible for PEP. Eight patients (23%) who did not know the HIV status of their partner would have been eligible considering single exposure as a sufficient criterion for PEP. Oro-genital contact appears to account for transmission in four instances. Eleven persons (31%) were infected after sexual contact with their stable partner, of whom 7 did not known his/her HIV status. Twelve patients (34%) were infected after multiple unprotected sexual contact with unknown partners.

CONCLUSION

The direct impact of PEP in terms of HIV infections prevented is likely to be small. PEP will not make up for the failure of other prevention methods. It may, however, contribute to the disclosure and the discussion of risk situations and help physicians provide individual counselling taking into account the precise context of risk behavior.

Authors+Show Affiliations

Institut de médecine sociale et préventive, Université de Genève, Suisse. philippe.sudre@medecine.unige.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

10189668

Citation

Sudre, P, et al. "[Post-exposure HIV Prevention: Eligibility of Patients Recently Infected By Sexual Exposure]." Schweizerische Medizinische Wochenschrift, vol. 129, no. 8, 1999, pp. 314-8.
Sudre P, San Millán Ruiz D, Fagard C, et al. [Post-exposure HIV prevention: eligibility of patients recently infected by sexual exposure]. Schweiz Med Wochenschr. 1999;129(8):314-8.
Sudre, P., San Millán Ruiz, D., Fagard, C., Perrin, L., & Hirschel, B. J. (1999). [Post-exposure HIV prevention: eligibility of patients recently infected by sexual exposure]. Schweizerische Medizinische Wochenschrift, 129(8), 314-8.
Sudre P, et al. [Post-exposure HIV Prevention: Eligibility of Patients Recently Infected By Sexual Exposure]. Schweiz Med Wochenschr. 1999 Feb 27;129(8):314-8. PubMed PMID: 10189668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Post-exposure HIV prevention: eligibility of patients recently infected by sexual exposure]. AU - Sudre,P, AU - San Millán Ruiz,D, AU - Fagard,C, AU - Perrin,L, AU - Hirschel,B J, PY - 1999/4/6/pubmed PY - 1999/4/6/medline PY - 1999/4/6/entrez SP - 314 EP - 8 JF - Schweizerische medizinische Wochenschrift JO - Schweiz Med Wochenschr VL - 129 IS - 8 N2 - QUESTION: Post-exposure prophylaxis (PEP) is effective in preventing HIV infection after professional exposure. PEP is also recommended after inadvertent sexual exposure if two conditions are met: the source person is known to be HIV infected, and exposure to this person occurred only once or is accidental. The objective of this study is to describe the circumstances of sexual exposure and determine how frequently these conditions were present among patients diagnosed during primary HIV infection. METHODS: Physicians of 35 patients diagnosed with primary HIV infection provided detailed information on the circumstances of infection as well as on the patients and source persons. RESULTS: Most patients were homosexual (71%), and 91% were male. Only one patient (3%) had a single exposure with a known HIV-infected person and was therefore eligible for PEP. Eight patients (23%) who did not know the HIV status of their partner would have been eligible considering single exposure as a sufficient criterion for PEP. Oro-genital contact appears to account for transmission in four instances. Eleven persons (31%) were infected after sexual contact with their stable partner, of whom 7 did not known his/her HIV status. Twelve patients (34%) were infected after multiple unprotected sexual contact with unknown partners. CONCLUSION: The direct impact of PEP in terms of HIV infections prevented is likely to be small. PEP will not make up for the failure of other prevention methods. It may, however, contribute to the disclosure and the discussion of risk situations and help physicians provide individual counselling taking into account the precise context of risk behavior. SN - 0036-7672 UR - https://www.unboundmedicine.com/medline/citation/10189668/[Post_exposure_HIV_prevention:_eligibility_of_patients_recently_infected_by_sexual_exposure]_ L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -