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Antimicrobial spectrum of Alchornea cordifolia leaf extract.
Phytother Res. 1999 Feb; 13(1):67-9.PR

Abstract

The 50% aqueous ethanol extract of Alchornea cordifolia (Schum and Thonn) Muell. Arg. leaf was screened for activity against 74 microbial strains representing aerobic, facultative and anaerobic bacteria as well as fungi. The panel of test strains included organisms from culture collections as well as clinical and environmental isolates. A concentration of 5 mg/mL of extract inhibited 36.5% of the isolates and 95.9% were inhibited by a concentration of 20 mg/mL. Only three strains, all filamentous fungi, were not susceptible to 40 mg/mL of the extract, the highest concentration tested. The extract showed the best activity against gram-positive bacteria and yeasts with inhibitory concentrations against these organisms being under 5 mg/mL. The results demonstrate that the A. cordifolia extract has a very broad spectrum of activity and suggests that it may be useful in the treatment of various microbial infections.

Authors+Show Affiliations

Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10189955

Citation

Okeke, I N., et al. "Antimicrobial Spectrum of Alchornea Cordifolia Leaf Extract." Phytotherapy Research : PTR, vol. 13, no. 1, 1999, pp. 67-9.
Okeke IN, Ogundaini AO, Ogungbamila FO, et al. Antimicrobial spectrum of Alchornea cordifolia leaf extract. Phytother Res. 1999;13(1):67-9.
Okeke, I. N., Ogundaini, A. O., Ogungbamila, F. O., & Lamikanra, A. (1999). Antimicrobial spectrum of Alchornea cordifolia leaf extract. Phytotherapy Research : PTR, 13(1), 67-9.
Okeke IN, et al. Antimicrobial Spectrum of Alchornea Cordifolia Leaf Extract. Phytother Res. 1999;13(1):67-9. PubMed PMID: 10189955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial spectrum of Alchornea cordifolia leaf extract. AU - Okeke,I N, AU - Ogundaini,A O, AU - Ogungbamila,F O, AU - Lamikanra,A, PY - 1999/4/6/pubmed PY - 1999/4/6/medline PY - 1999/4/6/entrez SP - 67 EP - 9 JF - Phytotherapy research : PTR JO - Phytother Res VL - 13 IS - 1 N2 - The 50% aqueous ethanol extract of Alchornea cordifolia (Schum and Thonn) Muell. Arg. leaf was screened for activity against 74 microbial strains representing aerobic, facultative and anaerobic bacteria as well as fungi. The panel of test strains included organisms from culture collections as well as clinical and environmental isolates. A concentration of 5 mg/mL of extract inhibited 36.5% of the isolates and 95.9% were inhibited by a concentration of 20 mg/mL. Only three strains, all filamentous fungi, were not susceptible to 40 mg/mL of the extract, the highest concentration tested. The extract showed the best activity against gram-positive bacteria and yeasts with inhibitory concentrations against these organisms being under 5 mg/mL. The results demonstrate that the A. cordifolia extract has a very broad spectrum of activity and suggests that it may be useful in the treatment of various microbial infections. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/10189955/Antimicrobial_spectrum_of_Alchornea_cordifolia_leaf_extract_ L2 - https://doi.org/10.1002/(SICI)1099-1573(199902)13:1<67::AID-PTR366>3.0.CO;2-F DB - PRIME DP - Unbound Medicine ER -