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Antiviral activity of some South American medicinal plants.
Phytother Res. 1999 Mar; 13(2):142-6.PR

Abstract

Folk medicinal plants are potential sources of useful therapeutic compounds including some with antiviral activities. Extracts prepared from 10 South American medicinal plants (Baccharis trinervis, Baccharis teindalensis, Eupatorium articulatum, Eupatorium glutinosum, Tagetes pusilla, Neurolaena lobata, Conyza floribunda, Phytolacca bogotensis, Phytolacca rivinoides and Heisteria acuminata) were screened for in vitro antiviral activity against herpes simplex type I (HSV-1), vesicular stomatitis virus (VSV) and poliovirus type 1. The most potent inhibition was observed with an aqueous extract of B. trinervis, which inhibited HSV-1 replication by 100% at 50-200 micrograms/mL, without showing cytotoxic effects. Good activities were also found with the ethanol extract of H. acuminata and the aqueous extract of E. articulatum, which exhibited antiviral effects against both DNA and RNA viruses (HSV-1 and VSV, respectively) at 125-250 micrograms/mL. The aqueous extracts of T. pusilla (100-250 micrograms/mL), B. teindalensis (50-125 micrograms/mL) and E. glutinosum (50-125 micrograms/mL) also inhibited the replication of VSV, but none of the extracts tested had any effect on poliovirus replication.

Authors+Show Affiliations

Abad MJ
Departamento de Farmacologia, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Bermejo P
No affiliation info available
Sanchez Palomino S
No affiliation info available
Chiriboga X
No affiliation info available
Carrasco L
No affiliation info available

MeSH

Antiviral AgentsDrug Evaluation, PreclinicalHeLa CellsHerpesvirus 1, HumanHumansPhytotherapyPlant ExtractsPlants, MedicinalPoliovirusSouth AmericaVesicular stomatitis Indiana virus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10190189

Citation

Abad, M J., et al. "Antiviral Activity of some South American Medicinal Plants." Phytotherapy Research : PTR, vol. 13, no. 2, 1999, pp. 142-6.
Abad MJ, Bermejo P, Sanchez Palomino S, et al. Antiviral activity of some South American medicinal plants. Phytother Res. 1999;13(2):142-6.
Abad, M. J., Bermejo, P., Sanchez Palomino, S., Chiriboga, X., & Carrasco, L. (1999). Antiviral activity of some South American medicinal plants. Phytotherapy Research : PTR, 13(2), 142-6.
Abad MJ, et al. Antiviral Activity of some South American Medicinal Plants. Phytother Res. 1999;13(2):142-6. PubMed PMID: 10190189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiviral activity of some South American medicinal plants. AU - Abad,M J, AU - Bermejo,P, AU - Sanchez Palomino,S, AU - Chiriboga,X, AU - Carrasco,L, PY - 1999/4/6/pubmed PY - 1999/4/6/medline PY - 1999/4/6/entrez SP - 142 EP - 6 JF - Phytotherapy research : PTR JO - Phytother Res VL - 13 IS - 2 N2 - Folk medicinal plants are potential sources of useful therapeutic compounds including some with antiviral activities. Extracts prepared from 10 South American medicinal plants (Baccharis trinervis, Baccharis teindalensis, Eupatorium articulatum, Eupatorium glutinosum, Tagetes pusilla, Neurolaena lobata, Conyza floribunda, Phytolacca bogotensis, Phytolacca rivinoides and Heisteria acuminata) were screened for in vitro antiviral activity against herpes simplex type I (HSV-1), vesicular stomatitis virus (VSV) and poliovirus type 1. The most potent inhibition was observed with an aqueous extract of B. trinervis, which inhibited HSV-1 replication by 100% at 50-200 micrograms/mL, without showing cytotoxic effects. Good activities were also found with the ethanol extract of H. acuminata and the aqueous extract of E. articulatum, which exhibited antiviral effects against both DNA and RNA viruses (HSV-1 and VSV, respectively) at 125-250 micrograms/mL. The aqueous extracts of T. pusilla (100-250 micrograms/mL), B. teindalensis (50-125 micrograms/mL) and E. glutinosum (50-125 micrograms/mL) also inhibited the replication of VSV, but none of the extracts tested had any effect on poliovirus replication. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/10190189/Antiviral_activity_of_some_South_American_medicinal_plants_ L2 - https://doi.org/10.1002/(SICI)1099-1573(199903)13:2<142::AID-PTR392>3.0.CO;2-7 DB - PRIME DP - Unbound Medicine ER -