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Prevalence and clinical importance of Helicobacter pylori infection in patients after partial gastric resection for peptic ulcer disease. A prospective evaluation of Helicobacter pylori infection on 50 resected patients compared with matched nonresected controls.
Z Gastroenterol. 1999 Feb; 37(2):127-32.ZG

Abstract

There have been only a few surveys on the prevalence of persistent Helicobacter pylori (Hp) infection in patients who have undergone surgery for peptic ulceration. The aim of the study was to evaluate the prevalence and clinical importance of Hp infection after partial gastric surgery due to peptic ulcer disease.

METHODS

We examined 50 patients who had partial gastric resection for peptic ulcer disease and years later underwent upper gastrointestinal (GI) endoscopy. 50 controls matched with respect to indication for GI endoscopy, age and gender were also studied. Three specimens from the fundus of gastric remnant were examined for Hp infection (histology and rapid urease test). The prevalence of Hp infection and pathology findings were compared between the two groups using chi-square statistics.

RESULTS

32 men and 18 women were examined (40 x BII, 10 x BI). The prevalence of Hp infection was 38% in the resected group compared to 60% in the control group (p = 0.015). We found a significant association (p = 0.0004) between Hp infection and endoscopic findings in the control group but not in the group of partially resected patients (p = 0.66).

CONCLUSION

The prevalence of Hp infection in hospitalized patients with partial gastric resection is significantly lower than in matched controls. Hp infection does not play a significant pathogenic role in recurrent ulcer after partial gastric resection in these patients.

Authors+Show Affiliations

Schilling D
Medical Department C, Klinikum Ludwigshafen, Academic Hospital of the University of Mainz.
Adamek HE
No affiliation info available
Wilke J
No affiliation info available
Schauwecker P
No affiliation info available
Martin WR
No affiliation info available
Arnold JC
No affiliation info available
Benz C
No affiliation info available
Labenz J
No affiliation info available
Riemann JF
No affiliation info available

MeSH

AdultAgedAged, 80 and overBiopsyCross-Sectional StudiesFemaleGastric StumpGastroscopyGermanyHelicobacter InfectionsHelicobacter pyloriHumansIncidenceMaleMiddle AgedPeptic UlcerPostgastrectomy Syndromes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10190245

Citation

Schilling, D, et al. "Prevalence and Clinical Importance of Helicobacter Pylori Infection in Patients After Partial Gastric Resection for Peptic Ulcer Disease. a Prospective Evaluation of Helicobacter Pylori Infection On 50 Resected Patients Compared With Matched Nonresected Controls." Zeitschrift Fur Gastroenterologie, vol. 37, no. 2, 1999, pp. 127-32.
Schilling D, Adamek HE, Wilke J, et al. Prevalence and clinical importance of Helicobacter pylori infection in patients after partial gastric resection for peptic ulcer disease. A prospective evaluation of Helicobacter pylori infection on 50 resected patients compared with matched nonresected controls. Z Gastroenterol. 1999;37(2):127-32.
Schilling, D., Adamek, H. E., Wilke, J., Schauwecker, P., Martin, W. R., Arnold, J. C., Benz, C., Labenz, J., & Riemann, J. F. (1999). Prevalence and clinical importance of Helicobacter pylori infection in patients after partial gastric resection for peptic ulcer disease. A prospective evaluation of Helicobacter pylori infection on 50 resected patients compared with matched nonresected controls. Zeitschrift Fur Gastroenterologie, 37(2), 127-32.
Schilling D, et al. Prevalence and Clinical Importance of Helicobacter Pylori Infection in Patients After Partial Gastric Resection for Peptic Ulcer Disease. a Prospective Evaluation of Helicobacter Pylori Infection On 50 Resected Patients Compared With Matched Nonresected Controls. Z Gastroenterol. 1999;37(2):127-32. PubMed PMID: 10190245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and clinical importance of Helicobacter pylori infection in patients after partial gastric resection for peptic ulcer disease. A prospective evaluation of Helicobacter pylori infection on 50 resected patients compared with matched nonresected controls. AU - Schilling,D, AU - Adamek,H E, AU - Wilke,J, AU - Schauwecker,P, AU - Martin,W R, AU - Arnold,J C, AU - Benz,C, AU - Labenz,J, AU - Riemann,J F, PY - 1999/4/6/pubmed PY - 1999/4/6/medline PY - 1999/4/6/entrez SP - 127 EP - 32 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 37 IS - 2 N2 - UNLABELLED: There have been only a few surveys on the prevalence of persistent Helicobacter pylori (Hp) infection in patients who have undergone surgery for peptic ulceration. The aim of the study was to evaluate the prevalence and clinical importance of Hp infection after partial gastric surgery due to peptic ulcer disease. METHODS: We examined 50 patients who had partial gastric resection for peptic ulcer disease and years later underwent upper gastrointestinal (GI) endoscopy. 50 controls matched with respect to indication for GI endoscopy, age and gender were also studied. Three specimens from the fundus of gastric remnant were examined for Hp infection (histology and rapid urease test). The prevalence of Hp infection and pathology findings were compared between the two groups using chi-square statistics. RESULTS: 32 men and 18 women were examined (40 x BII, 10 x BI). The prevalence of Hp infection was 38% in the resected group compared to 60% in the control group (p = 0.015). We found a significant association (p = 0.0004) between Hp infection and endoscopic findings in the control group but not in the group of partially resected patients (p = 0.66). CONCLUSION: The prevalence of Hp infection in hospitalized patients with partial gastric resection is significantly lower than in matched controls. Hp infection does not play a significant pathogenic role in recurrent ulcer after partial gastric resection in these patients. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/10190245/Prevalence_and_clinical_importance_of_Helicobacter_pylori_infection_in_patients_after_partial_gastric_resection_for_peptic_ulcer_disease__A_prospective_evaluation_of_Helicobacter_pylori_infection_on_50_resected_patients_compared_with_matched_nonresected_controls_ L2 - https://medlineplus.gov/pepticulcer.html DB - PRIME DP - Unbound Medicine ER -