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Cytochrome b phylogeny of North American hares and jackrabbits (Lepus, lagomorpha) and the effects of saturation in outgroup taxa.
Mol Phylogenet Evol. 1999 Mar; 11(2):213-21.MP

Abstract

Jackrabbits and hares, members of the genus Lepus, comprise over half of the species within the family Leporidae (Lagomorpha). Despite their ecological importance, potential economic impact, and worldwide distribution, the evolution of hares and jackrabbits has been poorly studied. We provide an initial phylogenetic framework for jackrabbits and hares so that explicit hypotheses about their evolution can be developed and tested. To this end, we have collected DNA sequence data from a 702-bp region of the mitochondrial cytochrome b gene and reconstructed the evolutionary history (via parsimony, neighbor joining, and maximum likelihood) of 11 species of Lepus, focusing on North American taxa. Due to problems of saturation, induced by multiple substitutions, at synonymous coding positions between the ingroup taxa and the outgroups (Oryctolagus and Sylvilagus), both rooted and unrooted trees were examined. Variation in tree topologies generated by different reconstruction methods was observed in analyses including the outgroups, but not in the analyses of unrooted ingroup networks. Apparently, substitutional saturation hindered the analyses when outgroups were considered. The trees based on the cytochrome b data indicate that the taxonomic status of some species needs to be reassessed and that species of Lepus within North America do not form a monophyletic entity.

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Authors+Show Affiliations

Halanych KM
Department of Zoology and Entomology, University of Pretoria, Pretoria, 0002, South Africa.
Demboski JR
No affiliation info available
van Vuuren BJ
No affiliation info available
Klein DR
No affiliation info available
Cook JA
No affiliation info available

MeSH

AnimalsCytochrome b GroupEvolution, MolecularLagomorphaModels, BiologicalNorth AmericaPhylogenySpecies Specificity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10191066

Citation

Halanych, K M., et al. "Cytochrome B Phylogeny of North American Hares and Jackrabbits (Lepus, Lagomorpha) and the Effects of Saturation in Outgroup Taxa." Molecular Phylogenetics and Evolution, vol. 11, no. 2, 1999, pp. 213-21.
Halanych KM, Demboski JR, van Vuuren BJ, et al. Cytochrome b phylogeny of North American hares and jackrabbits (Lepus, lagomorpha) and the effects of saturation in outgroup taxa. Mol Phylogenet Evol. 1999;11(2):213-21.
Halanych, K. M., Demboski, J. R., van Vuuren, B. J., Klein, D. R., & Cook, J. A. (1999). Cytochrome b phylogeny of North American hares and jackrabbits (Lepus, lagomorpha) and the effects of saturation in outgroup taxa. Molecular Phylogenetics and Evolution, 11(2), 213-21.
Halanych KM, et al. Cytochrome B Phylogeny of North American Hares and Jackrabbits (Lepus, Lagomorpha) and the Effects of Saturation in Outgroup Taxa. Mol Phylogenet Evol. 1999;11(2):213-21. PubMed PMID: 10191066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytochrome b phylogeny of North American hares and jackrabbits (Lepus, lagomorpha) and the effects of saturation in outgroup taxa. AU - Halanych,K M, AU - Demboski,J R, AU - van Vuuren,B J, AU - Klein,D R, AU - Cook,J A, PY - 1999/4/7/pubmed PY - 1999/4/7/medline PY - 1999/4/7/entrez SP - 213 EP - 21 JF - Molecular phylogenetics and evolution JO - Mol Phylogenet Evol VL - 11 IS - 2 N2 - Jackrabbits and hares, members of the genus Lepus, comprise over half of the species within the family Leporidae (Lagomorpha). Despite their ecological importance, potential economic impact, and worldwide distribution, the evolution of hares and jackrabbits has been poorly studied. We provide an initial phylogenetic framework for jackrabbits and hares so that explicit hypotheses about their evolution can be developed and tested. To this end, we have collected DNA sequence data from a 702-bp region of the mitochondrial cytochrome b gene and reconstructed the evolutionary history (via parsimony, neighbor joining, and maximum likelihood) of 11 species of Lepus, focusing on North American taxa. Due to problems of saturation, induced by multiple substitutions, at synonymous coding positions between the ingroup taxa and the outgroups (Oryctolagus and Sylvilagus), both rooted and unrooted trees were examined. Variation in tree topologies generated by different reconstruction methods was observed in analyses including the outgroups, but not in the analyses of unrooted ingroup networks. Apparently, substitutional saturation hindered the analyses when outgroups were considered. The trees based on the cytochrome b data indicate that the taxonomic status of some species needs to be reassessed and that species of Lepus within North America do not form a monophyletic entity. SN - 1055-7903 UR - https://www.unboundmedicine.com/medline/citation/10191066/Cytochrome_b_phylogeny_of_North_American_hares_and_jackrabbits__Lepus_lagomorpha__and_the_effects_of_saturation_in_outgroup_taxa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1055-7903(98)90581-4 DB - PRIME DP - Unbound Medicine ER -