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Analysis of hepatitis G virus (HGV) RNA, antibody to HGV envelope protein, and risk factors for blood donors coinfected with HGV and hepatitis C virus.
J Infect Dis. 1999 May; 179(5):1055-61.JI

Abstract

Serologic, biochemical, and molecular analyses were used to study hepatitis G virus (HGV), antibody to the HGV envelope protein (anti-E2), risk factors, clinical significance, and the impact of HGV on coexistent hepatitis C virus (HCV). Among 329 donors with confirmed HCV infection, 12% were HGV RNA-positive and 44% were anti-E2-positive (total exposure, 56%). HGV RNA and anti-E2 were mutually exclusive except in 9 donors (1.5%); 8 of 9 subsequently lost HGV RNA but anti-E2 persisted. HGV had little impact on alanine aminotransferase, aspartate aminotransferase, or gamma-glutamyl transpeptidase in donors with HGV infection alone or those coinfected with HCV. A multivariate analysis showed that intravenous drug abuse was the leading risk factor for HGV transmission, followed by blood transfusion, snorting cocaine, imprisonment, and a history of sexually transmitted diseases. In summary, HGV and HCV infections were frequently associated and shared common parenteral risk factors; HGV did not appear to cause hepatitis or to worsen the course of coexistent hepatitis C.

Authors+Show Affiliations

National Institutes of Health, Laboratory for Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Resaerch, Food and Drug Administration, Bethesda, Bethesda, MD, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10191204

Citation

Tan, D, et al. "Analysis of Hepatitis G Virus (HGV) RNA, Antibody to HGV Envelope Protein, and Risk Factors for Blood Donors Coinfected With HGV and Hepatitis C Virus." The Journal of Infectious Diseases, vol. 179, no. 5, 1999, pp. 1055-61.
Tan D, Matsumoto A, Conry-Cantilena C, et al. Analysis of hepatitis G virus (HGV) RNA, antibody to HGV envelope protein, and risk factors for blood donors coinfected with HGV and hepatitis C virus. J Infect Dis. 1999;179(5):1055-61.
Tan, D., Matsumoto, A., Conry-Cantilena, C., Melpolder, J. C., Shih, J. W., Leuther, M., Hess, G., Gibble, J. W., Ness, P. M., & Alter, H. J. (1999). Analysis of hepatitis G virus (HGV) RNA, antibody to HGV envelope protein, and risk factors for blood donors coinfected with HGV and hepatitis C virus. The Journal of Infectious Diseases, 179(5), 1055-61.
Tan D, et al. Analysis of Hepatitis G Virus (HGV) RNA, Antibody to HGV Envelope Protein, and Risk Factors for Blood Donors Coinfected With HGV and Hepatitis C Virus. J Infect Dis. 1999;179(5):1055-61. PubMed PMID: 10191204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of hepatitis G virus (HGV) RNA, antibody to HGV envelope protein, and risk factors for blood donors coinfected with HGV and hepatitis C virus. AU - Tan,D, AU - Matsumoto,A, AU - Conry-Cantilena,C, AU - Melpolder,J C, AU - Shih,J W, AU - Leuther,M, AU - Hess,G, AU - Gibble,J W, AU - Ness,P M, AU - Alter,H J, PY - 1999/4/7/pubmed PY - 2000/3/21/medline PY - 1999/4/7/entrez SP - 1055 EP - 61 JF - The Journal of infectious diseases JO - J Infect Dis VL - 179 IS - 5 N2 - Serologic, biochemical, and molecular analyses were used to study hepatitis G virus (HGV), antibody to the HGV envelope protein (anti-E2), risk factors, clinical significance, and the impact of HGV on coexistent hepatitis C virus (HCV). Among 329 donors with confirmed HCV infection, 12% were HGV RNA-positive and 44% were anti-E2-positive (total exposure, 56%). HGV RNA and anti-E2 were mutually exclusive except in 9 donors (1.5%); 8 of 9 subsequently lost HGV RNA but anti-E2 persisted. HGV had little impact on alanine aminotransferase, aspartate aminotransferase, or gamma-glutamyl transpeptidase in donors with HGV infection alone or those coinfected with HCV. A multivariate analysis showed that intravenous drug abuse was the leading risk factor for HGV transmission, followed by blood transfusion, snorting cocaine, imprisonment, and a history of sexually transmitted diseases. In summary, HGV and HCV infections were frequently associated and shared common parenteral risk factors; HGV did not appear to cause hepatitis or to worsen the course of coexistent hepatitis C. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10191204/Analysis_of_hepatitis_G_virus__HGV__RNA_antibody_to_HGV_envelope_protein_and_risk_factors_for_blood_donors_coinfected_with_HGV_and_hepatitis_C_virus_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/314722 DB - PRIME DP - Unbound Medicine ER -