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A prospective study of alcohol consumption and the risk of age-related macular degeneration.
Ann Epidemiol 1999; 9(3):172-7AE

Abstract

PURPOSE

Vascular risk factors, including alcohol intake, have been hypothesized to play a role in the development of age-related macular degeneration (AMD). We examined the relationship of alcohol intake with AMD in the Physicians' Health Study (PHS).

METHODS

The PHS was a randomized trial of aspirin and beta-carotene among 22,071 U.S. male physicians age 40 to 84 years at entry. A total of 21,041 physicians with complete data on alcohol consumption and no AMD at baseline were included in this analysis. Proportional hazards models were used to estimate relative risks (RR) and 95% confidence interval (CI).

RESULTS

During an average follow-up period of 12.5 years, 278 physicians were confirmed by medical record review to have incident AMD resulting in vision loss (acuity 20/30 or worse). After adjusting for age, randomized treatment assignment, and other potential risk factors, the RR for > or = 1 drink/week versus < 1 drink/week was 0.97 (CI: 0.78-1.21). For categories of alcohol intake, the RRs for those reporting alcohol consumption of < 1 drink/week, 1 drink/week, 2-4 drinks/week, 5-6 drinks/week, and > or = 1 drink/day were 1.00 (referent), 1.00 (0.65-1.55), 0.68 (0.44-1.04), 1.32 (0.89-1.95), and 1.27 (0.93-1.73), respectively.

CONCLUSIONS

These prospective data indicate that alcohol intake is not appreciably associated with the risk of incident AMD. However, the width of the confidence intervals are compatible with a possible small effect (reduction or increase) in risk for low to moderate levels of alcohol intake, which warrant further investigation.

Authors+Show Affiliations

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215-1204, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10192649

Citation

Ajani, U A., et al. "A Prospective Study of Alcohol Consumption and the Risk of Age-related Macular Degeneration." Annals of Epidemiology, vol. 9, no. 3, 1999, pp. 172-7.
Ajani UA, Christen WG, Manson JE, et al. A prospective study of alcohol consumption and the risk of age-related macular degeneration. Ann Epidemiol. 1999;9(3):172-7.
Ajani, U. A., Christen, W. G., Manson, J. E., Glynn, R. J., Schaumberg, D., Buring, J. E., & Hennekens, C. H. (1999). A prospective study of alcohol consumption and the risk of age-related macular degeneration. Annals of Epidemiology, 9(3), pp. 172-7.
Ajani UA, et al. A Prospective Study of Alcohol Consumption and the Risk of Age-related Macular Degeneration. Ann Epidemiol. 1999;9(3):172-7. PubMed PMID: 10192649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of alcohol consumption and the risk of age-related macular degeneration. AU - Ajani,U A, AU - Christen,W G, AU - Manson,J E, AU - Glynn,R J, AU - Schaumberg,D, AU - Buring,J E, AU - Hennekens,C H, PY - 1999/4/7/pubmed PY - 1999/4/7/medline PY - 1999/4/7/entrez SP - 172 EP - 7 JF - Annals of epidemiology JO - Ann Epidemiol VL - 9 IS - 3 N2 - PURPOSE: Vascular risk factors, including alcohol intake, have been hypothesized to play a role in the development of age-related macular degeneration (AMD). We examined the relationship of alcohol intake with AMD in the Physicians' Health Study (PHS). METHODS: The PHS was a randomized trial of aspirin and beta-carotene among 22,071 U.S. male physicians age 40 to 84 years at entry. A total of 21,041 physicians with complete data on alcohol consumption and no AMD at baseline were included in this analysis. Proportional hazards models were used to estimate relative risks (RR) and 95% confidence interval (CI). RESULTS: During an average follow-up period of 12.5 years, 278 physicians were confirmed by medical record review to have incident AMD resulting in vision loss (acuity 20/30 or worse). After adjusting for age, randomized treatment assignment, and other potential risk factors, the RR for > or = 1 drink/week versus < 1 drink/week was 0.97 (CI: 0.78-1.21). For categories of alcohol intake, the RRs for those reporting alcohol consumption of < 1 drink/week, 1 drink/week, 2-4 drinks/week, 5-6 drinks/week, and > or = 1 drink/day were 1.00 (referent), 1.00 (0.65-1.55), 0.68 (0.44-1.04), 1.32 (0.89-1.95), and 1.27 (0.93-1.73), respectively. CONCLUSIONS: These prospective data indicate that alcohol intake is not appreciably associated with the risk of incident AMD. However, the width of the confidence intervals are compatible with a possible small effect (reduction or increase) in risk for low to moderate levels of alcohol intake, which warrant further investigation. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/10192649/A_prospective_study_of_alcohol_consumption_and_the_risk_of_age_related_macular_degeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047279798000532 DB - PRIME DP - Unbound Medicine ER -