Tags

Type your tag names separated by a space and hit enter

Hereditary deficiency of vitamin-K-dependent coagulation factors in Rambouillet sheep.
Blood Coagul Fibrinolysis 1999; 10(2):75-80BC

Abstract

A flock of Rambouillet sheep experienced unexpected lamb mortality associated with excessive bleeding at the time of parturition. Most lambs died of blood loss through the umbilicus or into subcutaneous tissues. Subsequently, nine ewes which had previously delivered lambs that bled to death were bred to the suspected sire of the previous bleeding lambs. Fifteen lambs were born alive the following Spring, and three males and one female bled clinically. These lambs had markedly decreased factor IX (< 16%) and factor X (< 4%) activities, with variably decreased factor II (11-36%) and factor VII (20-37%) activities. Protein C chromogenic activity was also markedly decreased (< 1%) in these lambs. The results from crossed immunoelectrophoresis and 'protein-induced-in-vitamin-K-absence' determination of the plasma of affected lambs, with antiserum directed against coagulation factor X, protein C or proteins S, suggested that these proteins were not carboxylated normally. Examination of liver from one lamb in the first batch and the four subsequent lambs did not reveal a known vitamin K antagonist. The breeding data suggested that the coagulopathy in these sheep was inherited as an autosomal recessive trait. The genetic or molecular defect that exists in these lambs is unknown, but possibilities include abnormal gamma-glutamyl carboxylase activity or abnormal metabolism of vitamin K.

Authors+Show Affiliations

Department of Pathology, College of Veterinary Medicine, Colorado State University, Fort Collins 80523, USA. dcbaker@lamar.colostate.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10192655

Citation

Baker, D C., et al. "Hereditary Deficiency of vitamin-K-dependent Coagulation Factors in Rambouillet Sheep." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 10, no. 2, 1999, pp. 75-80.
Baker DC, Robbe SL, Jacobson L, et al. Hereditary deficiency of vitamin-K-dependent coagulation factors in Rambouillet sheep. Blood Coagul Fibrinolysis. 1999;10(2):75-80.
Baker, D. C., Robbe, S. L., Jacobson, L., Manco-Johnson, M. J., Holler, L., & Lefkowitz, J. (1999). Hereditary deficiency of vitamin-K-dependent coagulation factors in Rambouillet sheep. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 10(2), pp. 75-80.
Baker DC, et al. Hereditary Deficiency of vitamin-K-dependent Coagulation Factors in Rambouillet Sheep. Blood Coagul Fibrinolysis. 1999;10(2):75-80. PubMed PMID: 10192655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary deficiency of vitamin-K-dependent coagulation factors in Rambouillet sheep. AU - Baker,D C, AU - Robbe,S L, AU - Jacobson,L, AU - Manco-Johnson,M J, AU - Holler,L, AU - Lefkowitz,J, PY - 1999/4/7/pubmed PY - 1999/4/7/medline PY - 1999/4/7/entrez SP - 75 EP - 80 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul. Fibrinolysis VL - 10 IS - 2 N2 - A flock of Rambouillet sheep experienced unexpected lamb mortality associated with excessive bleeding at the time of parturition. Most lambs died of blood loss through the umbilicus or into subcutaneous tissues. Subsequently, nine ewes which had previously delivered lambs that bled to death were bred to the suspected sire of the previous bleeding lambs. Fifteen lambs were born alive the following Spring, and three males and one female bled clinically. These lambs had markedly decreased factor IX (< 16%) and factor X (< 4%) activities, with variably decreased factor II (11-36%) and factor VII (20-37%) activities. Protein C chromogenic activity was also markedly decreased (< 1%) in these lambs. The results from crossed immunoelectrophoresis and 'protein-induced-in-vitamin-K-absence' determination of the plasma of affected lambs, with antiserum directed against coagulation factor X, protein C or proteins S, suggested that these proteins were not carboxylated normally. Examination of liver from one lamb in the first batch and the four subsequent lambs did not reveal a known vitamin K antagonist. The breeding data suggested that the coagulopathy in these sheep was inherited as an autosomal recessive trait. The genetic or molecular defect that exists in these lambs is unknown, but possibilities include abnormal gamma-glutamyl carboxylase activity or abnormal metabolism of vitamin K. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/10192655/Hereditary_deficiency_of_vitamin_K_dependent_coagulation_factors_in_Rambouillet_sheep_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=10192655.ui DB - PRIME DP - Unbound Medicine ER -