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Influenza vaccination of human immunodeficiency virus (HIV)-infected adults: impact on plasma levels of HIV type 1 RNA and determinants of antibody response.
Clin Infect Dis 1999; 28(3):541-7CI

Abstract

We assessed the effect of influenza vaccination on plasma levels of human immunodeficiency virus type 1 (HIV-1) RNA and the impact of age, plasma HIV-1 RNA level, CD4 cell count, and anti-HIV therapy on immune response. Forty-nine adults (mean age, 38.7 years; mean CD4 cell count +/- SD, 190 +/- 169/mL; mean plasma HIV-1 RNA level +/- SD, 154,616 +/- 317,192 copies/mL) were immunized. Elevations of > or = 0.48 log in plasma HIV-1 RNA levels occurred in two (4%) of 49 subjects within 4 weeks of vaccination. A fourfold or greater increase in antibody titer occurred in 13 (45%) of 29 subjects, correlating directly with CD4 cell count (P = .002) and inversely with plasma HIV-1 RNA level (P = .034). By multivariate analysis, CD4 cell count was a stronger predictor of antibody response than was plasma HIV-1 RNA level. We conclude that increases in plasma HIV-1 RNA levels following influenza vaccination are rare and transient and that antibody response is impaired with CD4 cell counts of < 100/mL and plasma HIV-1 RNA levels of > 100,000 copies/mL. Prospective trials are needed to evaluate the impact of highly active therapy on immune response after vaccination.

Authors+Show Affiliations

Department of Medicine, Boston University School of Medicine and Boston Medical Center, Massachusetts 02118, USA. jfuller@bu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10194075

Citation

Fuller, J D., et al. "Influenza Vaccination of Human Immunodeficiency Virus (HIV)-infected Adults: Impact On Plasma Levels of HIV Type 1 RNA and Determinants of Antibody Response." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 28, no. 3, 1999, pp. 541-7.
Fuller JD, Craven DE, Steger KA, et al. Influenza vaccination of human immunodeficiency virus (HIV)-infected adults: impact on plasma levels of HIV type 1 RNA and determinants of antibody response. Clin Infect Dis. 1999;28(3):541-7.
Fuller, J. D., Craven, D. E., Steger, K. A., Cox, N., Heeren, T. C., & Chernoff, D. (1999). Influenza vaccination of human immunodeficiency virus (HIV)-infected adults: impact on plasma levels of HIV type 1 RNA and determinants of antibody response. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 28(3), pp. 541-7.
Fuller JD, et al. Influenza Vaccination of Human Immunodeficiency Virus (HIV)-infected Adults: Impact On Plasma Levels of HIV Type 1 RNA and Determinants of Antibody Response. Clin Infect Dis. 1999;28(3):541-7. PubMed PMID: 10194075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza vaccination of human immunodeficiency virus (HIV)-infected adults: impact on plasma levels of HIV type 1 RNA and determinants of antibody response. AU - Fuller,J D, AU - Craven,D E, AU - Steger,K A, AU - Cox,N, AU - Heeren,T C, AU - Chernoff,D, PY - 1999/4/8/pubmed PY - 1999/4/8/medline PY - 1999/4/8/entrez SP - 541 EP - 7 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 28 IS - 3 N2 - We assessed the effect of influenza vaccination on plasma levels of human immunodeficiency virus type 1 (HIV-1) RNA and the impact of age, plasma HIV-1 RNA level, CD4 cell count, and anti-HIV therapy on immune response. Forty-nine adults (mean age, 38.7 years; mean CD4 cell count +/- SD, 190 +/- 169/mL; mean plasma HIV-1 RNA level +/- SD, 154,616 +/- 317,192 copies/mL) were immunized. Elevations of > or = 0.48 log in plasma HIV-1 RNA levels occurred in two (4%) of 49 subjects within 4 weeks of vaccination. A fourfold or greater increase in antibody titer occurred in 13 (45%) of 29 subjects, correlating directly with CD4 cell count (P = .002) and inversely with plasma HIV-1 RNA level (P = .034). By multivariate analysis, CD4 cell count was a stronger predictor of antibody response than was plasma HIV-1 RNA level. We conclude that increases in plasma HIV-1 RNA levels following influenza vaccination are rare and transient and that antibody response is impaired with CD4 cell counts of < 100/mL and plasma HIV-1 RNA levels of > 100,000 copies/mL. Prospective trials are needed to evaluate the impact of highly active therapy on immune response after vaccination. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/10194075/Influenza_vaccination_of_human_immunodeficiency_virus__HIV__infected_adults:_impact_on_plasma_levels_of_HIV_type_1_RNA_and_determinants_of_antibody_response_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/515170 DB - PRIME DP - Unbound Medicine ER -