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Successful oral doxycycline treatment of Lyme disease-associated facial palsy and meningitis.
Clin Infect Dis. 1999 Mar; 28(3):569-74.CI

Abstract

Twenty-nine patients, aged 11-79 years (mean, 50 years), with Lyme neuroborreliosis, facial nerve palsy, and meningitis were treated with oral doxycycline (daily dose, 200-400 mg) for 9-17 days in a prospective, nonrandomized study. Facial paresis was bilateral in eight (28%) of the 29 patients. Twenty-six patients (90%) recovered without sequelae within 6 months, while three of the patients with bilateral facial palsy at admission had remaining paresis at follow-up. In five patients, contralateral facial paresis developed 1-12 days after initiation of therapy, and two patients were retreated with antibiotics. Posttreatment examinations of cerebrospinal fluid showed a marked decrease of inflammatory cells and protein concentrations compared with pretreatment levels in all followed up patients. The favorable clinical outcome agrees with findings of other reports on intravenous antibiotic therapy for Lyme disease-associated meningitis with facial palsy. Our conclusion is that oral doxycycline is an effective and convenient therapy for Lyme disease-associated facial palsy.

Authors+Show Affiliations

Department of Infectious Diseases, Institute of Internal Medicine, Göteborg University, Sweden. leif.dotevall@medfak.gu.seNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10194080

Citation

Dotevall, L, and L Hagberg. "Successful Oral Doxycycline Treatment of Lyme Disease-associated Facial Palsy and Meningitis." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 28, no. 3, 1999, pp. 569-74.
Dotevall L, Hagberg L. Successful oral doxycycline treatment of Lyme disease-associated facial palsy and meningitis. Clin Infect Dis. 1999;28(3):569-74.
Dotevall, L., & Hagberg, L. (1999). Successful oral doxycycline treatment of Lyme disease-associated facial palsy and meningitis. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 28(3), 569-74.
Dotevall L, Hagberg L. Successful Oral Doxycycline Treatment of Lyme Disease-associated Facial Palsy and Meningitis. Clin Infect Dis. 1999;28(3):569-74. PubMed PMID: 10194080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful oral doxycycline treatment of Lyme disease-associated facial palsy and meningitis. AU - Dotevall,L, AU - Hagberg,L, PY - 1999/4/8/pubmed PY - 2000/5/20/medline PY - 1999/4/8/entrez SP - 569 EP - 74 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 28 IS - 3 N2 - Twenty-nine patients, aged 11-79 years (mean, 50 years), with Lyme neuroborreliosis, facial nerve palsy, and meningitis were treated with oral doxycycline (daily dose, 200-400 mg) for 9-17 days in a prospective, nonrandomized study. Facial paresis was bilateral in eight (28%) of the 29 patients. Twenty-six patients (90%) recovered without sequelae within 6 months, while three of the patients with bilateral facial palsy at admission had remaining paresis at follow-up. In five patients, contralateral facial paresis developed 1-12 days after initiation of therapy, and two patients were retreated with antibiotics. Posttreatment examinations of cerebrospinal fluid showed a marked decrease of inflammatory cells and protein concentrations compared with pretreatment levels in all followed up patients. The favorable clinical outcome agrees with findings of other reports on intravenous antibiotic therapy for Lyme disease-associated meningitis with facial palsy. Our conclusion is that oral doxycycline is an effective and convenient therapy for Lyme disease-associated facial palsy. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/10194080/Successful_oral_doxycycline_treatment_of_Lyme_disease_associated_facial_palsy_and_meningitis_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/515145 DB - PRIME DP - Unbound Medicine ER -