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Omega-3 fatty acids in adipose tissue and risk of myocardial infarction: the EURAMIC study.
Arterioscler Thromb Vasc Biol 1999; 19(4):1111-8AT

Abstract

Omega-3 fatty acids have potential antiatherogenic, antithrombotic, and antiarrhythmic properties, but their role in coronary heart disease remains controversial. To evaluate the association of omega-3 fatty acids in adipose tissue with the risk of myocardial infarction in men, a case-control study was conducted in eight European countries and Israel. Cases (n=639) included patients with a first myocardial infarction admitted to coronary care units within 24 hours from the onset of symptoms. Controls (n=700) were selected to represent the populations originating the cases. Adipose tissue levels of fatty acids were determined by capillary gas chromatography. The mean (+/-SD) proportion of alpha-linolenic acid was 0.77% (+/-0.19) of fatty acids in cases and 0.80% (+/-0.19) of fatty acids in controls (P=0.01). The relative risk for the highest quintile of alpha-linolenic acid compared with the lowest was 0.42 (95% confidence interval [CI] 0.22 to 0.81, P-trend=0.02). After adjusting for classical risk factors, the relative risk for the highest quintile was 0.68 (95% CI 0.31 to 1.49, P-trend=0.38). The mean proportion of docosahexaenoic acid was 0.24% (+/-0.13) of fatty acids in cases and 0.25% (+/-0.13) of fatty acids in controls (P=0. 14), with no evidence of association with risk of myocardial infarction. In this large case-control study we could not detect a protective effect of docosahexaenoic acid on the risk of myocardial infarction. The protective effect of alpha-linolenic acid was attenuated after adjusting for classical risk factors (mainly smoking), but it deserves further research.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, National School of Public Health, "Instituto de Salud Carlos III", Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10195943

Citation

Guallar, E, et al. "Omega-3 Fatty Acids in Adipose Tissue and Risk of Myocardial Infarction: the EURAMIC Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 19, no. 4, 1999, pp. 1111-8.
Guallar E, Aro A, Jiménez FJ, et al. Omega-3 fatty acids in adipose tissue and risk of myocardial infarction: the EURAMIC study. Arterioscler Thromb Vasc Biol. 1999;19(4):1111-8.
Guallar, E., Aro, A., Jiménez, F. J., Martín-Moreno, J. M., Salminen, I., van't Veer, P., ... Kok, F. J. (1999). Omega-3 fatty acids in adipose tissue and risk of myocardial infarction: the EURAMIC study. Arteriosclerosis, Thrombosis, and Vascular Biology, 19(4), pp. 1111-8.
Guallar E, et al. Omega-3 Fatty Acids in Adipose Tissue and Risk of Myocardial Infarction: the EURAMIC Study. Arterioscler Thromb Vasc Biol. 1999;19(4):1111-8. PubMed PMID: 10195943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids in adipose tissue and risk of myocardial infarction: the EURAMIC study. AU - Guallar,E, AU - Aro,A, AU - Jiménez,F J, AU - Martín-Moreno,J M, AU - Salminen,I, AU - van't Veer,P, AU - Kardinaal,A F, AU - Gómez-Aracena,J, AU - Martin,B C, AU - Kohlmeier,L, AU - Kark,J D, AU - Mazaev,V P, AU - Ringstad,J, AU - Guillén,J, AU - Riemersma,R A, AU - Huttunen,J K, AU - Thamm,M, AU - Kok,F J, PY - 1999/4/9/pubmed PY - 1999/4/9/medline PY - 1999/4/9/entrez SP - 1111 EP - 8 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 19 IS - 4 N2 - Omega-3 fatty acids have potential antiatherogenic, antithrombotic, and antiarrhythmic properties, but their role in coronary heart disease remains controversial. To evaluate the association of omega-3 fatty acids in adipose tissue with the risk of myocardial infarction in men, a case-control study was conducted in eight European countries and Israel. Cases (n=639) included patients with a first myocardial infarction admitted to coronary care units within 24 hours from the onset of symptoms. Controls (n=700) were selected to represent the populations originating the cases. Adipose tissue levels of fatty acids were determined by capillary gas chromatography. The mean (+/-SD) proportion of alpha-linolenic acid was 0.77% (+/-0.19) of fatty acids in cases and 0.80% (+/-0.19) of fatty acids in controls (P=0.01). The relative risk for the highest quintile of alpha-linolenic acid compared with the lowest was 0.42 (95% confidence interval [CI] 0.22 to 0.81, P-trend=0.02). After adjusting for classical risk factors, the relative risk for the highest quintile was 0.68 (95% CI 0.31 to 1.49, P-trend=0.38). The mean proportion of docosahexaenoic acid was 0.24% (+/-0.13) of fatty acids in cases and 0.25% (+/-0.13) of fatty acids in controls (P=0. 14), with no evidence of association with risk of myocardial infarction. In this large case-control study we could not detect a protective effect of docosahexaenoic acid on the risk of myocardial infarction. The protective effect of alpha-linolenic acid was attenuated after adjusting for classical risk factors (mainly smoking), but it deserves further research. SN - 1079-5642 UR - https://www.unboundmedicine.com/medline/citation/10195943/Omega_3_fatty_acids_in_adipose_tissue_and_risk_of_myocardial_infarction:_the_EURAMIC_study_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.atv.19.4.1111?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -