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Association and linkage analysis of candidate chromosomal regions in multiple sclerosis: indication of disease genes in 12q23 and 7ptr-15.
Eur J Hum Genet. 1999 Feb-Mar; 7(2):110-6.EJ

Abstract

Four recent genome-wide screen studies in multiple sclerosis (MS) identified a number of candidate regions for susceptibility genes in addition to the HLA complex in 6p21. However, none of these regions provided formally significant evidence for genome-wide linkage. We have investigated such regions in 46 Swedish multiplex MS families, 28 singleton families, 190 sporadic MS patients and 148 normal controls by parametric and nonparametric linkage and association analysis. One microsatellite marker, in 12q23, provided evidence for association in addition to suggestive transmission distortion and slightly positive linkage. In addition, a marker in 7ptr-15 showed a significant transmission distortion as well as a highly significant score in affected pedigree member analysis, but not quite significant deviations in association analysis. One of three markers in 5p, a region implicated in all four previous studies, showed a weakly positive lod score, but no other evidence of importance. Markers in 2p23, 5q11-13, 6q25, 7q21-22, 11q21-23, 13q33-34, 16p13.2, 18p11.32-23, Xp21.3 provided little or no evidence of importance for MS. In summary, these data support the importance of genome-wide screens in the identification of new candidate loci in polygenic disorders.

Authors+Show Affiliations

Department of Neurology, Karolinska Institute, Huddinge University Hospital, Sweden. chun.xu@cnsf.ki.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10196692

Citation

Xu, C, et al. "Association and Linkage Analysis of Candidate Chromosomal Regions in Multiple Sclerosis: Indication of Disease Genes in 12q23 and 7ptr-15." European Journal of Human Genetics : EJHG, vol. 7, no. 2, 1999, pp. 110-6.
Xu C, Dai Y, Fredrikson S, et al. Association and linkage analysis of candidate chromosomal regions in multiple sclerosis: indication of disease genes in 12q23 and 7ptr-15. Eur J Hum Genet. 1999;7(2):110-6.
Xu, C., Dai, Y., Fredrikson, S., & Hillert, J. (1999). Association and linkage analysis of candidate chromosomal regions in multiple sclerosis: indication of disease genes in 12q23 and 7ptr-15. European Journal of Human Genetics : EJHG, 7(2), 110-6.
Xu C, et al. Association and Linkage Analysis of Candidate Chromosomal Regions in Multiple Sclerosis: Indication of Disease Genes in 12q23 and 7ptr-15. Eur J Hum Genet. 1999;7(2):110-6. PubMed PMID: 10196692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association and linkage analysis of candidate chromosomal regions in multiple sclerosis: indication of disease genes in 12q23 and 7ptr-15. AU - Xu,C, AU - Dai,Y, AU - Fredrikson,S, AU - Hillert,J, PY - 1999/4/10/pubmed PY - 1999/4/10/medline PY - 1999/4/10/entrez SP - 110 EP - 6 JF - European journal of human genetics : EJHG JO - Eur. J. Hum. Genet. VL - 7 IS - 2 N2 - Four recent genome-wide screen studies in multiple sclerosis (MS) identified a number of candidate regions for susceptibility genes in addition to the HLA complex in 6p21. However, none of these regions provided formally significant evidence for genome-wide linkage. We have investigated such regions in 46 Swedish multiplex MS families, 28 singleton families, 190 sporadic MS patients and 148 normal controls by parametric and nonparametric linkage and association analysis. One microsatellite marker, in 12q23, provided evidence for association in addition to suggestive transmission distortion and slightly positive linkage. In addition, a marker in 7ptr-15 showed a significant transmission distortion as well as a highly significant score in affected pedigree member analysis, but not quite significant deviations in association analysis. One of three markers in 5p, a region implicated in all four previous studies, showed a weakly positive lod score, but no other evidence of importance. Markers in 2p23, 5q11-13, 6q25, 7q21-22, 11q21-23, 13q33-34, 16p13.2, 18p11.32-23, Xp21.3 provided little or no evidence of importance for MS. In summary, these data support the importance of genome-wide screens in the identification of new candidate loci in polygenic disorders. SN - 1018-4813 UR - https://www.unboundmedicine.com/medline/citation/10196692/Association_and_linkage_analysis_of_candidate_chromosomal_regions_in_multiple_sclerosis:_indication_of_disease_genes_in_12q23_and_7ptr_15_ L2 - http://dx.doi.org/10.1038/sj.ejhg.5200251 DB - PRIME DP - Unbound Medicine ER -