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Synergistic effects of anthraquinones on the purgative activity of rhein anthrone in mice.
J Pharm Pharmacol. 1999 Jan; 51(1):93-5.JP

Abstract

This study was performed to determine whether intracaecally administered rhein anthrone and anthraquinones such as aloe-emodin, chrysophanol, emodin or rhein synergistically enhance the purgative action as has been observed for rhein anthrone and aloe-emodin anthrone. These anthraquinones were less potent than rhein anthrone. An equimolar mixture of aloe-emodin and rhein anthrone had synergistic potentiating effects because the ED50 value (50% purgative dose) of the combination was smaller than that calculated additively from the ED50 values of aloe-emodin and rhein anthrone. An equimolar mixture of other anthraquinones and rhein anthrone tended to potentiate the purgative action. These results confirmed that rhein anthrone and aloe-emodin synergistically exert a purgative action as has been observed for rhein anthrone and aloe-emodin anthrone.

Authors+Show Affiliations

Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10197424

Citation

Yagi, T, and K Yamauchi. "Synergistic Effects of Anthraquinones On the Purgative Activity of Rhein Anthrone in Mice." The Journal of Pharmacy and Pharmacology, vol. 51, no. 1, 1999, pp. 93-5.
Yagi T, Yamauchi K. Synergistic effects of anthraquinones on the purgative activity of rhein anthrone in mice. J Pharm Pharmacol. 1999;51(1):93-5.
Yagi, T., & Yamauchi, K. (1999). Synergistic effects of anthraquinones on the purgative activity of rhein anthrone in mice. The Journal of Pharmacy and Pharmacology, 51(1), 93-5.
Yagi T, Yamauchi K. Synergistic Effects of Anthraquinones On the Purgative Activity of Rhein Anthrone in Mice. J Pharm Pharmacol. 1999;51(1):93-5. PubMed PMID: 10197424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergistic effects of anthraquinones on the purgative activity of rhein anthrone in mice. AU - Yagi,T, AU - Yamauchi,K, PY - 1999/4/10/pubmed PY - 1999/4/10/medline PY - 1999/4/10/entrez SP - 93 EP - 5 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 51 IS - 1 N2 - This study was performed to determine whether intracaecally administered rhein anthrone and anthraquinones such as aloe-emodin, chrysophanol, emodin or rhein synergistically enhance the purgative action as has been observed for rhein anthrone and aloe-emodin anthrone. These anthraquinones were less potent than rhein anthrone. An equimolar mixture of aloe-emodin and rhein anthrone had synergistic potentiating effects because the ED50 value (50% purgative dose) of the combination was smaller than that calculated additively from the ED50 values of aloe-emodin and rhein anthrone. An equimolar mixture of other anthraquinones and rhein anthrone tended to potentiate the purgative action. These results confirmed that rhein anthrone and aloe-emodin synergistically exert a purgative action as has been observed for rhein anthrone and aloe-emodin anthrone. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/10197424/Synergistic_effects_of_anthraquinones_on_the_purgative_activity_of_rhein_anthrone_in_mice_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3573&date=1999&volume=51&issue=1&spage=93 DB - PRIME DP - Unbound Medicine ER -