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Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout.
J Ethnopharmacol. 1999 Feb; 64(2):149-60.JE

Abstract

Xanthine oxidase (xanthine: oxygen oxidoreductase EC 1.2.3.2) inhibitory activity was assayed from 26 species belonging to 18 families traditionally used for the treatment of gout and related symptoms by Indigenous people of northeastern North America. The degree of inhibition was determined by measuring the increase in absorbance at 295 nm associated with uric acid formation. Eighty-eight percent of the plants were found to have inhibitory activity at 100 microg/ml, with 20% having greater than 50% inhibition. Larix laricina exhibited the highest activity with an inhibition of 86.33%. Of the species with the highest activity, Lineweaver-Burk plots showed that inhibition mode was of linear mixed-type. Inhibitory activity of the plants correlated positively with their phenolic content (r = 0.52 P < 0.01) and tannin content (r = 0.59 P < 0.001).

Authors+Show Affiliations

Department of Plant Science, McGill University, Ste-Anne-de-Bellevue, Qué, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10197750

Citation

Owen, P L., and T Johns. "Xanthine Oxidase Inhibitory Activity of Northeastern North American Plant Remedies Used for Gout." Journal of Ethnopharmacology, vol. 64, no. 2, 1999, pp. 149-60.
Owen PL, Johns T. Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout. J Ethnopharmacol. 1999;64(2):149-60.
Owen, P. L., & Johns, T. (1999). Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout. Journal of Ethnopharmacology, 64(2), 149-60.
Owen PL, Johns T. Xanthine Oxidase Inhibitory Activity of Northeastern North American Plant Remedies Used for Gout. J Ethnopharmacol. 1999;64(2):149-60. PubMed PMID: 10197750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout. AU - Owen,P L, AU - Johns,T, PY - 1999/4/10/pubmed PY - 1999/4/10/medline PY - 1999/4/10/entrez SP - 149 EP - 60 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 64 IS - 2 N2 - Xanthine oxidase (xanthine: oxygen oxidoreductase EC 1.2.3.2) inhibitory activity was assayed from 26 species belonging to 18 families traditionally used for the treatment of gout and related symptoms by Indigenous people of northeastern North America. The degree of inhibition was determined by measuring the increase in absorbance at 295 nm associated with uric acid formation. Eighty-eight percent of the plants were found to have inhibitory activity at 100 microg/ml, with 20% having greater than 50% inhibition. Larix laricina exhibited the highest activity with an inhibition of 86.33%. Of the species with the highest activity, Lineweaver-Burk plots showed that inhibition mode was of linear mixed-type. Inhibitory activity of the plants correlated positively with their phenolic content (r = 0.52 P < 0.01) and tannin content (r = 0.59 P < 0.001). SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/10197750/Xanthine_oxidase_inhibitory_activity_of_northeastern_North_American_plant_remedies_used_for_gout_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378874198001196 DB - PRIME DP - Unbound Medicine ER -